Substituent Effects on the Basicity of Patriscabrin A and Lettucenin A: Evolution Favors the Aromatic?

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2021 Nov 15

PMID 34778640

Authors

Supreeth Prasad

Dean J Tantillo

Affiliations

Soon will be listed here.

Abstract

Basicities for derivatives of patriscabrin A and lettucenin A were calculated with density functional theory. A significant correlation is observed between the basicity and Hammett σ parameters. Protonation increases the aromatic character of the cyclic moieties of each natural product. The naturally occurring structures are predicted to be the most aromatic.

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