Korean Red Ginseng Exerts Anti-inflammatory and Autophagy-promoting Activities in Aged Mice

Overview

Journal J Ginseng Res

Date 2021 Nov 12

PMID 34764726

Citations 24

Authors

Jin Kyeong Kim

Kon Kuk Shin

Haeyeop Kim

Yo Han Hong

Wooram Choi

Yi-Seong Kwak

Chang-Kyun Han

Sun Hee Hyun

Jae Youl Cho

Affiliations

Soon will be listed here.

Abstract

Background: Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period.

Methods: The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis.

Results: KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1 MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach.

Conclusion: The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice.

Citing Articles

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