Autophagy and Its Regulation by Ginseng Components

Overview

Journal J Ginseng Res

Date 2019 Jul 17

PMID 31308805

Citations 11

Authors

Nurinanda Prisky Qomaladewi

Mi-Yeon Kim

Jae Youl Cho

Affiliations

Soon will be listed here.

Abstract

Autophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. In this review, we describe a plant extract that is well known in Korea, namely Korean ginseng extract; we studied how its derivatives and metabolites can regulate autophagy and thus mediate the pathogenesis of certain diseases.

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