Metformin As a Tool to Target Aging

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2016 Jun 16

PMID 27304507

Citations 469

Authors

Nir Barzilai

Jill P Crandall

Stephen B Kritchevsky

Mark A Espeland

Affiliations

Soon will be listed here.

Abstract

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

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