Genetic Code Expansion Through Quadruplet Codon Decoding

Overview

Journal J Mol Biol

Publisher Elsevier

Specialties Microbiology
Molecular Biology

Date 2021 Nov 11

PMID 34762896

Citations 14

Authors

Jiantao Guo

Wei Niu

Affiliations

Soon will be listed here.

Abstract

Noncanonical amino acid mutagenesis has emerged as a powerful tool for the study of protein structure and function. While triplet nonsense codons, especially the amber codon, have been widely employed, quadruplet codons have attracted attention for the potential of creating additional blank codons for noncanonical amino acids mutagenesis. In this review, we discuss methodologies and applications of quadruplet codon decoding in genetic code expansion both in vitro and in vivo.

Citing Articles

Quadruplet codon decoding-based versatile genetic biocontainment system.

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Cellular Site-Specific Incorporation of Noncanonical Amino Acids in Synthetic Biology.

Niu W, Guo J Chem Rev. 2024; 124(18):10577-10617.

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Tuning tRNAs for improved translation.

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Mechanisms and Delivery of tRNA Therapeutics.

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Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers.

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