Virucidal Activity in Vitro of Mouthwashes Against a Feline Coronavirus Type II

Overview

Journal Oral Dis

Specialty Dentistry

Date 2021 Nov 5

PMID 34739171

Citations 4

Authors

Alessio Buonavoglia

Michele Camero

Gianvito Lanave

Cristiana Catella

Claudia Maria Trombetta

Maria Giovanna Gandolfi

Gerardo Palazzo

Vito Martella

Carlo Prati

Affiliations

Soon will be listed here.

Abstract

Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur through saliva and aerosol droplets deriving from the upper aerodigestive tract during coughing, sneezing, talking, and even during oral inspection or dental procedures. The aim of this study was to assess in vitro virucidal activity of commercial and experimental mouthwashes against a feline coronavirus (FCoV) strain. Commercial and experimental (commercial-based products with addition of either sodium dodecyl sulfate (SDS) or thymus vulgaris essential oil (TEO) at different concentrations) mouthwashes were placed in contact with FCoV for different time intervals, that is, 30 s (T30), 60 s (T60), and 180 s (T180); subsequently, the virus was titrated on Crandell Reese Feline Kidney cells. An SDS-based commercial mouthwash reduced the viral load by 5 log10 tissue culture infectious dose (TCID) /50 µl at T30 while a cetylpyridinium (CPC)-based commercial mouthwash was able to reduce the viral titer of 4.75 log10 at T60. Furthermore, five experimental mouthwashes supplemented with SDS reduced the viral titer by 4.75-5 log10 according to a dose- (up to 4 mM) and time-dependent fashion.

Citing Articles

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Virucidal activity in vitro of mouthwashes against a feline coronavirus type II.

Buonavoglia A, Camero M, Lanave G, Catella C, Trombetta C, Gandolfi M Oral Dis. 2021; 28 Suppl 2:2492-2499.

PMID: 34739171 PMC: 9788155. DOI: 10.1111/odi.14067.

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