Obesity, Senescence, and Senolytics

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2021 Oct 26

PMID 34697668

Citations 9

Authors

Selim Chaib

Tamara Tchkonia

James L Kirkland

Affiliations

Soon will be listed here.

Abstract

Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs. Cellular senescence is a stress response that has been shown to be causally linked to aging and development of various age-related diseases such as obesity. The senescence-associated-secretory phenotype of senescent cells creates a chronic inflammatory milieu that leads to local and systemic dysfunction. The elimination of senescent cells using pharmacological approaches (i.e., senolytics) has been shown to delay, prevent, or alleviate obesity-related organ dysfunction.

Citing Articles

Obesity-associated Inflammation and Alloimmunity.

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PMID: 39192462 PMC: 11868468. DOI: 10.1097/TP.0000000000005183.

High-fat and high-carbohydrate diets increase bone fragility through TGF-β-dependent control of osteocyte function.

Dole N, Betancourt-Torres A, Kaya S, Obata Y, Schurman C, Yoon J JCI Insight. 2024; 9(16).

PMID: 39171528 PMC: 11343608. DOI: 10.1172/jci.insight.175103.

Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction.

Suda M, Paul K, Tripathi U, Minamino T, Tchkonia T, Kirkland J Endocr Rev. 2024; 45(5):655-675.

PMID: 38500373 PMC: 11405506. DOI: 10.1210/endrev/bnae010.

Effect of Cellular Senescence in Disease Progression and Transplantation: Immune Cells and Solid Organs.

Kirchner V, Badshah J, Hong S, Martinez O, Pruett T, Niedernhofer L Transplantation. 2023; 108(7):1509-1523.

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"Bone-SASP" in Skeletal Aging.

Fang C, Liu B, Wan M Calcif Tissue Int. 2023; 113(1):68-82.

PMID: 37256358 PMC: 10230496. DOI: 10.1007/s00223-023-01100-4.

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