Tamara Tchkonia
Overview
Explore the profile of Tamara Tchkonia including associated specialties, affiliations and a list of published articles.
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116
Citations
14615
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Recent Articles
1.
Millar C, Iloputaife I, Baldyga K, Norling A, Boulougoura A, Vichos T, et al.
EBioMedicine
. 2025 Feb;
113:105612.
PMID: 40010154
Background: This single-arm study evaluates the feasibility, safety, and preliminary effects of two senolytic agents, Dasatinib and Quercetin (DQ), in older adults at risk of Alzheimer's disease. Methods: Participants took...
2.
Tomimatsu N, Di Cristofaro L, Kanji S, Samentar L, Jordan B, Kittler R, et al.
EMBO Mol Med
. 2025 Feb;
PMID: 39972068
Glioblastomas (GBM) are routinely treated with high doses of ionizing radiation (IR), yet these tumors recur quickly, and the recurrent tumors are highly therapy resistant. Here, we report that IR-induced...
3.
Tilton M, Weivoda M, Potes M, Gingery A, Liu A, Tchkonia T, et al.
Aging Cell
. 2024 Nov;
23(12):e14421.
PMID: 39582140
Senescent osteocytes are key contributors to age-related bone loss and fragility; however, the impact of mechanobiological changes in these cells remains poorly understood. This study provides a novel analysis of...
4.
Silva M, Wacker D, Driver B, Staugaitis A, Niedernhofer L, Schmidt E, et al.
Trials
. 2024 Oct;
25(1):698.
PMID: 39434114
Background: Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these cells increases with age and emerging data implicate senescence-associated maladaptive signaling as a potential...
5.
Nath K, Juncos L, Singh R, Grande J, Croatt A, Ackerman A, et al.
Kidney360
. 2024 Oct;
PMID: 39418108
Background: Maturational failure of dialysis arteriovenous fistulas (AVFs) not uncommonly occurs and is of considerable and timely importance. Our prior studies demonstrate that senescence, a phenotypic process that promotes vascular...
6.
Tavenier J, Nehlin J, Houlind M, Rasmussen L, Tchkonia T, Kirkland J, et al.
Mech Ageing Dev
. 2024 Oct;
222:111995.
PMID: 39384074
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic agent for the treatment of age-related chronic diseases. Senotherapeutics...
7.
Yu G, Ganier C, Allison D, Tchkonia T, Khosla S, Kirkland J, et al.
Aging Cell
. 2024 Oct;
24(1):e14358.
PMID: 39370688
Single-cell RNA sequencing and spatial transcriptomics enable unprecedented insight into cellular and molecular pathways implicated in human skin aging and regeneration. Senescent cells are individual cells that are irreversibly cell...
8.
Farr J, Atkinson E, Achenbach S, Volkman T, Tweed A, Vos S, et al.
Nat Med
. 2024 Jul;
30(9):2605-2612.
PMID: 38956196
Preclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including bone loss. Thus, we conducted a phase 2 randomized controlled trial of intermittent...
9.
Shafqat A, Masters M, Tripathi U, Tchkonia T, Kirkland J, Hashmi S
Ageing Res Rev
. 2024 Jun;
99:102400.
PMID: 38945306
It has been four years since long COVID-the protracted consequences that survivors of COVID-19 face-was first described. Yet, this entity continues to devastate the quality of life of an increasing...
10.
Hambright W, Duke V, Goff A, Goff A, Minas L, Kloser H, et al.
Aging Cell
. 2024 May;
23(5):e14113.
PMID: 38708778
Chronic conditions associated with aging have proven difficult to prevent or treat. Senescence is a cell fate defined by loss of proliferative capacity and the development of a pro-inflammatory senescence-associated...