Molecular Characterization of Imported and Autochthonous Dengue in Northeastern Spain

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Oct 26

PMID 34696340

Citations 5

Authors

Jessica Navero-Castillejos

Rosa Benitez

Nuria Torner

Jose Munoz

Daniel Camprubi-Ferrer

Aida Peiro-Mestres

Elena Sulleiro

Aroa Silgado

Veronica Gonzalo

Teresa Falgueras

Izaskun Alejo-Cancho

Montserrat Roldan

Virginia Plasencia

Rosa Albarracin

Josefa Perez

Alexander Navarro

Ana Calderon

Rosa Rubio

Mireia Navarro

Miguel Mico

Jaume Llaberia

Maria Navarro

Josep Barrachina

Anna Vilamala

Carmina Marti

Maria Angeles Pulido

Maria Paz Sanchez-Seco

Ana Vazquez

Ana Martinez

Mireia Jane

Miguel Julian Martinez

Affiliations

Soon will be listed here.

Abstract

Dengue is the most significant arbovirus worldwide and a public health threat to non-endemic areas in which vectors are present. Autochthonous dengue transmission has been reported in several European countries in the last decade. Infected travelers from endemic regions arriving to areas colonized by in Europe need to be monitored in surveillance and control programs. We aimed to perform molecular characterization of RT-PCR-positive dengue cases detected in Catalonia, northeastern Spain, from 2013 to 2018. The basic demographic information and the geographical regions of importation were also analyzed. One-hundred four dengue cases were studied (103 imported infections and the first autochthonous case in our region). The dengue virus strains detected were serotyped and genotyped using molecular methods, and phylogenetic analyses were conducted. All four dengue serotypes were detected in travelers, including up to 10 different genotypes, reflecting the global circulation of dengue in endemic areas. The primary travel-related case of the 2018 autochthonous transmission was not identified, but the molecular analysis revealed dengue serotype 1, genotype I of Asian origin. Our results highlight the diversity of imported dengue virus strains and the role of molecular epidemiology in supporting arbovirus surveillance programs.

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