Understanding Dengue Virus Evolution to Support Epidemic Surveillance and Counter-measure Development

Overview

Journal Infect Genet Evol

Specialties Biology
Genetics
Infectious Diseases

Date 2018 Apr 29

PMID 29704626

Citations 36

Authors

S Pollett

M C Melendrez

I Maljkovic Berry

S Duchene

H Salje

D A T Cummings

R G Jarman

Affiliations

Soon will be listed here.

Abstract

Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae.aegypti and Ae.albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods. Here we provide a scoping overview of the evolution and molecular epidemiology of DENV and the range of ways that evolutionary analyses can be applied as a public health tool against this arboviral pathogen.

Citing Articles

Emergence of a Novel Dengue Virus Serotype-2 Genotype IV Lineage III Strain and Displacement of Dengue Virus Serotype-1 in Central India (2019-2023).

Yadav A, Chowdhary R, Siddiqui A, Malhotra A, Kanwar J, Kumar A Viruses. 2025; 17(2).

PMID: 40006899 PMC: 11861835. DOI: 10.3390/v17020144.

Molecular Epidemiology of Dengue Viruses in Lao People's Democratic Republic, 2020-2023.

Troupin C, Intavong K, Somlor S, Viengphouthong S, Keosenhom S, Chindavong T Microorganisms. 2025; 13(2).

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Independent repeated mutations within the alphaviruses Ross River virus and Barmah Forest virus indicates convergent evolution and past positive selection in ancestral populations despite ongoing purifying selection.

Pyke A, Wilson D, Michie A, Mackenzie J, Imrie A, Cameron J Virus Evol. 2024; 10(1):veae080.

PMID: 39411152 PMC: 11477980. DOI: 10.1093/ve/veae080.

Cryptic transmission and novel introduction of Dengue 1 and 2 genotypes in Colombia.

Martinez D, Gomez M, Hernandez C, Campo-Palacio S, Gonzalez-Robayo M, Montilla M Virus Evol. 2024; 10(1):veae068.

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Re-Emergence of DENV-3 in French Guiana: Retrospective Analysis of Cases That Circulated in the French Territories of the Americas from the 2000s to the 2023-2024 Outbreak.

Lagrave A, Enfissi A, Tirera S, Demar M, Jaonasoa J, Carod J Viruses. 2024; 16(8).

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