Preliminary Results on an Autochthonous Dengue Outbreak in Lombardy Region, Italy, August 2023

Overview

Journal Euro Surveill

Specialty Infectious Diseases

Date 2023 Sep 14

PMID 37707980

Authors

Irene Cassaniti

Guglielmo Ferrari

Sabrina Senatore

Eva Rossetti

Francesco Defilippo

Manuel Maffeo

Luigi Vezzosi

Giulia Campanini

Antonella Sarasini

Stefania Paolucci

Antonio Piralla

Davide Lelli

Ana Moreno

Maira Bonini

Marcello Tirani

Lorenzo Cerutti

Stefano Paglia

Angelo Regazzetti

Marco Farioli

Antonio Lavazza

Marino Faccini

Francesca Rovida

Danilo Cereda

Fausto Baldanti

Affiliations

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Abstract

In August 2023, six locally acquired dengue virus 1 infections were detected in Lodi province, Lombardy Region, in northern Italy, where the vector is present. Four cases were hospitalised, none died. The viruses clustered with Peruvian and Brazilian strains collected between 2021 and 2023. This preliminary report highlights the importance of continued integrated surveillance of imported vector-borne virus infections and the potential for tropical disease outbreaks in highly populated regions of northern Italy where competent vectors are present.

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References

Scaramozzino N, Crance J, Jouan A, DeBriel D, Stoll F, Garin D . Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol. 2001; 39(5):1922-7. PMC: 88049. DOI: 10.1128/JCM.39.5.1922-1927.2001. View

Lazzarini L, Barzon L, Foglia F, Manfrin V, Pacenti M, Pavan G . First autochthonous dengue outbreak in Italy, August 2020. Euro Surveill. 2020; 25(36). PMC: 7502902. DOI: 10.2807/1560-7917.ES.2020.25.36.2001606. View

Malavige G, Fernando S, Fernando D, Seneviratne S . Dengue viral infections. Postgrad Med J. 2004; 80(948):588-601. PMC: 1743110. DOI: 10.1136/pgmj.2004.019638. View

Huhtamo E, Hasu E, Uzcategui N, Erra E, Nikkari S, Kantele A . Early diagnosis of dengue in travelers: comparison of a novel real-time RT-PCR, NS1 antigen detection and serology. J Clin Virol. 2009; 47(1):49-53. DOI: 10.1016/j.jcv.2009.11.001. View

Auerswald H, de Jesus A, Seixas G, Nazareth T, In S, Mao S . First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation. Parasit Vectors. 2019; 12(1):103. PMC: 6417143. DOI: 10.1186/s13071-019-3357-3. View

Navero-Castillejos J, Benitez R, Torner N, Munoz J, Camprubi-Ferrer D, Peiro-Mestres A . Molecular Characterization of Imported and Autochthonous Dengue in Northeastern Spain. Viruses. 2021; 13(10). PMC: 8539074. DOI: 10.3390/v13101910. View

Gjenero-Margan I, Aleraj B, Krajcar D, Lesnikar V, Klobucar A, Pem-Novosel I . Autochthonous dengue fever in Croatia, August-September 2010. Euro Surveill. 2011; 16(9). View

Cochet A, Calba C, Jourdain F, Grard G, Durand G, Guinard A . Autochthonous dengue in mainland France, 2022: geographical extension and incidence increase. Euro Surveill. 2022; 27(44). PMC: 9635021. DOI: 10.2807/1560-7917.ES.2022.27.44.2200818. View

Romi R . [Aedes albopictus in Italy: an underestimated health problem]. Ann Ist Super Sanita. 2002; 37(2):241-7. View

10.

Rovida F, Percivalle E, Campanini G, Piralla A, Novati S, Muscatello A . Viremic Dengue virus infections in travellers: potential for local outbreak in Northern Italy. J Clin Virol. 2010; 50(1):76-9. DOI: 10.1016/j.jcv.2010.09.015. View

11.

Romi R . History and updating on the spread of Aedes albopictus in Italy. Parassitologia. 1995; 37(2-3):99-103. View

12.

Gubler D . Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002; 10(2):100-3. DOI: 10.1016/s0966-842x(01)02288-0. View

13.

La Ruche G, Souares Y, Armengaud A, Peloux-Petiot F, Delaunay P, Despres P . First two autochthonous dengue virus infections in metropolitan France, September 2010. Euro Surveill. 2010; 15(39):19676. View

14.

Alves M, Fernandes P, Amaro F, Osorio H, Luz T, Parreira P . Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira island, Portugal, October 2012. Euro Surveill. 2013; 18(6). View

15.

Borges V, Pinheiro M, Pechirra P, Guiomar R, Gomes J . INSaFLU: an automated open web-based bioinformatics suite "from-reads" for influenza whole-genome-sequencing-based surveillance. Genome Med. 2018; 10(1):46. PMC: 6027769. DOI: 10.1186/s13073-018-0555-0. View

16.

Linke S, Ellerbrok H, Niedrig M, Nitsche A, Pauli G . Detection of West Nile virus lineages 1 and 2 by real-time PCR. J Virol Methods. 2007; 146(1-2):355-8. DOI: 10.1016/j.jviromet.2007.05.021. View

17.

Bhatt S, Gething P, Brady O, Messina J, Farlow A, Moyes C . The global distribution and burden of dengue. Nature. 2013; 496(7446):504-7. PMC: 3651993. DOI: 10.1038/nature12060. View

18.

Wilder-Smith A, Ooi E, Horstick O, Wills B . Dengue. Lancet. 2019; 393(10169):350-363. DOI: 10.1016/S0140-6736(18)32560-1. View

19.

Piralla A, Borghesi A, Di Comite A, Giardina F, Ferrari G, Zanette S . Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023. Euro Surveill. 2023; 28(24). PMC: 10318938. DOI: 10.2807/1560-7917.ES.2023.28.24.2300289. View

20.

Barzon L, Gobbi F, Capelli G, Montarsi F, Martini S, Riccetti S . Autochthonous dengue outbreak in Italy 2020: clinical, virological and entomological findings. J Travel Med. 2021; 28(8). PMC: 8499737. DOI: 10.1093/jtm/taab130. View