The Recruitment Mechanisms and Potential Therapeutic Targets of Podocytes from Parietal Epithelial Cells

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2021 Oct 22

PMID 34674704

Citations 4

Authors

Lihua Ni

Cheng Yuan

Xiaoyan Wu

Affiliations

Soon will be listed here.

Abstract

Podocytes are differentiated postmitotic cells which cannot be replaced after podocyte injury. The mechanism of podocyte repopulation after injury has aroused wide concern. Parietal epithelial cells (PECs) are heterogeneous and only a specific subpopulation of PECs has the capacity to replace podocytes. Major progress has been achieved in recent years regarding the role and function of a subset of PECs which could transdifferentiate toward podocytes. Additionally, several factors, such as Notch, Wnt/ß-catenin, Wilms' tumor-1, miR-193a and growth arrest-specific protein 1, have been shown to be involved in these processes. Finally, PECs serve as a potential therapeutic target in the conditions of podocyte loss. In this review, we discuss the latest observations and concepts about the recruitment of podocytes from PECs in glomerular diseases as well as newly identified mechanisms and the most recent treatments for this process.

Citing Articles

(Zebra)fishing for nephrogenesis genes.

Chambers B, Weaver N, Lara C, Nguyen T, Wingert R Tissue Barriers. 2023; 12(2):2219605.

PMID: 37254823 PMC: 11042071. DOI: 10.1080/21688370.2023.2219605.

Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.

Drummond B, Ercanbrack W, Wingert R J Dev Biol. 2023; 11(1).

PMID: 36810461 PMC: 9944608. DOI: 10.3390/jdb11010009.

Cellular phenotypic transitions in diabetic nephropathy: An update.

Cao Y, Lin J, Hammes H, Zhang C Front Pharmacol. 2022; 13:1038073.

PMID: 36408221 PMC: 9666367. DOI: 10.3389/fphar.2022.1038073.

The Wnt Signaling Pathway in Diabetic Nephropathy.

Wang H, Zhang R, Wu X, Chen Y, Ji W, Wang J Front Cell Dev Biol. 2022; 9:701547.

PMID: 35059392 PMC: 8763969. DOI: 10.3389/fcell.2021.701547.

References

Migliorini A, Angelotti M, Mulay S, Kulkarni O, Demleitner J, Dietrich A . The antiviral cytokines IFN-α and IFN-β modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration. Am J Pathol. 2013; 183(2):431-40. DOI: 10.1016/j.ajpath.2013.04.017. View

Rizzo P, Novelli R, Rota C, Gagliardini E, Ruggiero B, Rottoli D . The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases. Am J Pathol. 2017; 187(11):2441-2450. DOI: 10.1016/j.ajpath.2017.07.004. View

Yadav A, Vallabu S, Kumar D, Ding G, Charney D, Chander P . HIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation. Am J Physiol Renal Physiol. 2009; 298(3):F734-44. PMC: 2838599. DOI: 10.1152/ajprenal.00415.2009. View

Sweetwyne M, Susztak K . For better or worse: a niche for Notch in parietal epithelial cell activation. Kidney Int. 2013; 83(6):988-90. PMC: 3671494. DOI: 10.1038/ki.2013.66. View

Zhou L, Li Y, He W, Zhou D, Tan R, Nie J . Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease. J Am Soc Nephrol. 2014; 26(3):677-91. PMC: 4341470. DOI: 10.1681/ASN.2013101067. View

Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C . Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS One. 2012; 7(4):e34907. PMC: 3329559. DOI: 10.1371/journal.pone.0034907. View

Hastie N . Wilms' tumour 1 (WT1) in development, homeostasis and disease. Development. 2017; 144(16):2862-2872. DOI: 10.1242/dev.153163. View

Smeets B, Kuppe C, Sicking E, Fuss A, Jirak P, van Kuppevelt T . Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2011; 22(7):1262-74. PMC: 3137574. DOI: 10.1681/ASN.2010090970. View

Zhang J, Hansen K, Pippin J, Chang A, Taniguchi Y, Krofft R . De novo expression of podocyte proteins in parietal epithelial cells in experimental aging nephropathy. Am J Physiol Renal Physiol. 2011; 302(5):F571-80. PMC: 3353646. DOI: 10.1152/ajprenal.00516.2011. View

10.

Kreidberg J, Sariola H, LORING J, Maeda M, Pelletier J, Housman D . WT-1 is required for early kidney development. Cell. 1993; 74(4):679-91. DOI: 10.1016/0092-8674(93)90515-r. View

11.

Pichaiwong W, Hudkins K, Wietecha T, Nguyen T, Tachaudomdach C, Li W . Reversibility of structural and functional damage in a model of advanced diabetic nephropathy. J Am Soc Nephrol. 2013; 24(7):1088-102. PMC: 3699819. DOI: 10.1681/ASN.2012050445. View

12.

Kato H, Susztak K . Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis. Semin Nephrol. 2012; 32(4):350-6. PMC: 3466477. DOI: 10.1016/j.semnephrol.2012.06.006. View

13.

Su H, Chen S, He F, Wang Y, Bondzie P, Zhang C . New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases. Biomed Res Int. 2015; 2015:318935. PMC: 4383425. DOI: 10.1155/2015/318935. View

14.

Kim M, Yoon S, Bollig F, Kitagaki J, Hur W, Whye N . A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. J Biol Chem. 2010; 285(19):14585-93. PMC: 2863207. DOI: 10.1074/jbc.M109.094334. View

15.

Smeets B, Uhlig S, Fuss A, Mooren F, Wetzels J, Floege J . Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells. J Am Soc Nephrol. 2009; 20(12):2604-15. PMC: 2794233. DOI: 10.1681/ASN.2009010122. View

16.

Chan G, Eng D, Miner J, Alpers C, Hudkins K, Chang A . Differential expression of parietal epithelial cell and podocyte extracellular matrix proteins in focal segmental glomerulosclerosis and diabetic nephropathy. Am J Physiol Renal Physiol. 2019; 317(6):F1680-F1694. PMC: 6962515. DOI: 10.1152/ajprenal.00266.2019. View

17.

Kim M, McGarry T, Broin P, Flatow J, Golden A, Licht J . An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1. Proc Natl Acad Sci U S A. 2009; 106(27):11154-9. PMC: 2708714. DOI: 10.1073/pnas.0901591106. View

18.

Xu Z, Fan J . Islet transplantation promotes podocyte regeneration in a model of diabetic nephropathy. Turk J Med Sci. 2018; 47(6):1925-1930. DOI: 10.3906/sag-1704-102. View

19.

Miller-Hodges E . Clinical Aspects of WT1 and the Kidney. Methods Mol Biol. 2016; 1467:15-21. DOI: 10.1007/978-1-4939-4023-3_2. View

20.

Kaverina N, Eng D, Miner J, Pippin J, Shankland S . Parietal epithelial cell differentiation to a podocyte fate in the aged mouse kidney. Aging (Albany NY). 2020; 12(17):17601-17624. PMC: 7521511. DOI: 10.18632/aging.103788. View