Metabolomics in Early Life and the Association with Body Composition at Age 2 years

Overview

Journal Pediatr Obes

Specialties Endocrinology
Pediatrics

Date 2021 Oct 13

PMID 34644810

Citations 6

Authors

Inge A L P van Beijsterveldt

Stuart G Snowden

Pernille Neve Myers

Kirsten S de Fluiter

Bert van de Heijning

Susanne Brix

Ken K Ong

David B Dunger

Anita C S Hokken-Koelega

Albert Koulman

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types.

Methods: In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age.

Results: Plasma metabolite-profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral-fat-skinfold-ratio (T:P-ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q = 0.322) than girls (Q = 0.117). Of the 15 metabolite variables most strongly associated with T:P-ratio, 11 were also associated with visceral fat at 2 years of age.

Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.

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