Temperature-Controlled Electrospray Ionization: Recent Progress and Applications

Overview

Journal Chemistry

Specialty Chemistry

Date 2021 Oct 11

PMID 34632657

Citations 1

Authors

Julian Alexander Harrison

Adam Pruska

Irina Oganesyan

Philipp Bittner

Renato Zenobi

Affiliations

Soon will be listed here.

Abstract

Native electrospray ionization (ESI) and nanoelectrospray ionization (nESI) allow researchers to analyze intact biomolecules and their complexes by mass spectrometry (MS). The data acquired using these soft ionization techniques provide a snapshot of a given biomolecules structure in solution. Over the last thirty years, several nESI and ESI sources capable of controlling spray solution temperature have been developed. These sources can be used to elucidate the thermodynamics of a given analyte, as well as provide structural information that cannot be readily obtained by other, more commonly used techniques. This review highlights how the field of temperature-controlled mass spectrometry has developed.

Citing Articles

Temperature-Controlled Electrospray Ionization: Recent Progress and Applications.

Alexander Harrison J, Pruska A, Oganesyan I, Bittner P, Zenobi R Chemistry. 2021; 27(72):18015-18028.

PMID: 34632657 PMC: 9298390. DOI: 10.1002/chem.202102474.

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