SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2021 Oct 7

PMID 34615369

Citations 12

Authors

Felicia Hartmann

Daniel J Gorski

Alexandra A C Newman

Susanne Homann

Anne Petz

Katherine M Owsiany

Vlad Serbulea

Yu-Qing Zhou

Rebecca A Deaton

Michelle Bendeck

Gary K Owens

Jens W Fischer

Affiliations

Soon will be listed here.

Abstract

[Figure: see text].

Citing Articles

Inhibition of Abdominal Aortic Aneurysm Progression Through the CXCL12/CXCR4 Axis via MiR206-3p Sponge.

Xuan X, Li Y, Cao G, Hu J, Yan S, Jin H J Cell Mol Med. 2025; 29(1):e70328.

PMID: 39779470 PMC: 11710933. DOI: 10.1111/jcmm.70328.

Big data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK.

Liu S, Wu J, Banerjee O, Xue B, Shi H, Ding Z Theranostics. 2025; 15(1):202-215.

PMID: 39744231 PMC: 11667232. DOI: 10.7150/thno.103851.

Vascular smooth muscle cell phenotypic switching in atherosclerosis.

Yu Y, Cai Y, Yang F, Yang Y, Cui Z, Shi D Heliyon. 2024; 10(18):e37727.

PMID: 39309965 PMC: 11416558. DOI: 10.1016/j.heliyon.2024.e37727.

Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells.

Jia K, Luo X, Yi J, Zhang C Biol Res. 2024; 57(1):61.

PMID: 39227995 PMC: 11373308. DOI: 10.1186/s40659-024-00542-w.

Understanding Galectin-3's Role in Diastolic Dysfunction: A Contemporary Perspective.

Hao W, Cheng C, Liu J, Chen H, Chen J, Cheng T Life (Basel). 2024; 14(7).

PMID: 39063659 PMC: 11277993. DOI: 10.3390/life14070906.

References

Danielson K, Baribault H, Holmes D, Graham H, Kadler K, Iozzo R . Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997; 136(3):729-43. PMC: 2134287. DOI: 10.1083/jcb.136.3.729. View

Nagy N, Freudenberger T, Melchior-Becker A, Rock K, ter Braak M, Jastrow H . Inhibition of hyaluronan synthesis accelerates murine atherosclerosis: novel insights into the role of hyaluronan synthesis. Circulation. 2010; 122(22):2313-22. DOI: 10.1161/CIRCULATIONAHA.110.972653. View

Allahverdian S, Chehroudi A, McManus B, Abraham T, Francis G . Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation. 2014; 129(15):1551-9. DOI: 10.1161/CIRCULATIONAHA.113.005015. View

Butler A, Hoffman P, Smibert P, Papalexi E, Satija R . Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018; 36(5):411-420. PMC: 6700744. DOI: 10.1038/nbt.4096. View

Kiene L, Homann S, Suvorava T, Rabausch B, Muller J, Kojda G . Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. Arterioscler Thromb Vasc Biol. 2015; 36(2):e9-16. PMC: 5222548. DOI: 10.1161/ATVBAHA.115.306607. View

Evanko S, Raines E, Ross R, Gold L, Wight T . Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta. Am J Pathol. 1998; 152(2):533-46. PMC: 1857967. View

Gomez D, Owens G . Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovasc Res. 2012; 95(2):156-64. PMC: 3388816. DOI: 10.1093/cvr/cvs115. View

Wang Y, Dubland J, Allahverdian S, Asonye E, Sahin B, Jaw J . Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019; 39(5):876-887. PMC: 6482082. DOI: 10.1161/ATVBAHA.119.312434. View

Shankman L, Gomez D, Cherepanova O, Salmon M, Alencar G, Haskins R . KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015; 21(6):628-37. PMC: 4552085. DOI: 10.1038/nm.3866. View

10.

Homann S, Grandoch M, Kiene L, Podsvyadek Y, Feldmann K, Rabausch B . Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. Matrix Biol. 2017; 66:67-80. PMC: 6023397. DOI: 10.1016/j.matbio.2017.09.005. View

11.

Durgin B, Cherepanova O, Gomez D, Karaoli T, Alencar G, Butcher J . Smooth muscle cell-specific deletion of unexpectedly leads to impaired development of advanced atherosclerotic lesions. Am J Physiol Heart Circ Physiol. 2017; 312(5):H943-H958. PMC: 5451587. DOI: 10.1152/ajpheart.00029.2017. View

12.

Alencar G, Owsiany K, Karnewar S, Sukhavasi K, Mocci G, Nguyen A . Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. Circulation. 2020; 142(21):2045-2059. PMC: 7682794. DOI: 10.1161/CIRCULATIONAHA.120.046672. View

13.

Hess D, Kelly-Goss M, Cherepanova O, Nguyen A, Baylis R, Tkachenko S . Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis. Nat Commun. 2019; 10(1):967. PMC: 6393549. DOI: 10.1038/s41467-019-08811-z. View

14.

Wirka R, Wagh D, Paik D, Pjanic M, Nguyen T, Miller C . Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nat Med. 2019; 25(8):1280-1289. PMC: 7274198. DOI: 10.1038/s41591-019-0512-5. View

15.

Shibata K, Sato K, Shirai R, Seki T, Okano T, Yamashita T . Lipocalin-2 exerts pro-atherosclerotic effects as evidenced by in vitro and in vivo experiments. Heart Vessels. 2020; 35(7):1012-1024. DOI: 10.1007/s00380-020-01556-6. View

16.

Del Monte-Nieto G, Fischer J, Gorski D, Harvey R, Kovacic J . Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar. J Am Coll Cardiol. 2020; 75(17):2169-2188. PMC: 7324287. DOI: 10.1016/j.jacc.2020.03.024. View

17.

Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D . PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements. Nucleic Acids Res. 2016; 45(D1):D183-D189. PMC: 5210595. DOI: 10.1093/nar/gkw1138. View

18.

Bentzon J, Otsuka F, Virmani R, Falk E . Mechanisms of plaque formation and rupture. Circ Res. 2014; 114(12):1852-66. DOI: 10.1161/CIRCRESAHA.114.302721. View

19.

Fischer J, Kinsella M, Levkau B, Clowes A, Wight T . Retroviral overexpression of decorin differentially affects the response of arterial smooth muscle cells to growth factors. Arterioscler Thromb Vasc Biol. 2001; 21(5):777-84. DOI: 10.1161/01.atv.21.5.777. View

20.

Pan H, Xue C, Auerbach B, Fan J, Bashore A, Cui J . Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human. Circulation. 2020; 142(21):2060-2075. PMC: 8104264. DOI: 10.1161/CIRCULATIONAHA.120.048378. View