Cytokine and Chemokine Responses in Invasive Aspergillosis Following Hematopoietic Stem Cell Transplantation: Past Evidence for Future Therapy of Aspergillosis

Overview

Journal J Fungi (Basel)

Date 2021 Sep 28

PMID 34575791

Citations 4

Authors

Patcharin Thammasit

Jirapas Sripetchwandee

Joshua D Nosanchuk

Siriporn C Chattipakorn

Nipon Chattipakorn

Sirida Youngchim

Affiliations

Soon will be listed here.

Abstract

Invasive pulmonary aspergillosis is a frequent complication in immunocompromised individuals, and it continues to be an important cause of mortality in patients undergoing hematopoietic stem cell transplantation. In addition to antifungal therapy used for mycoses, immune-modulatory molecules such as cytokines and chemokines can modify the host immune response and exhibit a promising form of antimicrobial therapeutics to combat invasive fungal diseases. Cytokine and chemokine profiles may also be applied as biomarkers during fungal infections and clinical research has demonstrated different activation patterns of cytokines in invasive mycoses such as aspergillosis. In this review, we summarize different aspects of cytokines that have been described to date and provide possible future directions in research on invasive pulmonary aspergillosis following hematopoietic stem cell transplantation. These findings suggest that cytokines and chemokines may serve as useful biomarkers to improve diagnosis and monitoring of infection.

Citing Articles

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Neuroimmune Responses in a New Experimental Animal Model of Cerebral Aspergillosis.

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References

Cunha C, Di Ianni M, Bozza S, Giovannini G, Zagarella S, Zelante T . Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood. 2010; 116(24):5394-402. DOI: 10.1182/blood-2010-04-279307. View

Willment J, Lin H, Reid D, Taylor P, Williams D, Wong S . Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide. J Immunol. 2003; 171(9):4569-73. DOI: 10.4049/jimmunol.171.9.4569. View

Chai L, de Boer M, van der Velden W, Plantinga T, Spriel A, Jacobs C . The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis. J Infect Dis. 2011; 203(5):736-43. PMC: 3072717. DOI: 10.1093/infdis/jiq102. View

Mehta R, Rezvani K . Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection. Virulence. 2016; 7(8):901-916. PMC: 5160395. DOI: 10.1080/21505594.2016.1208866. View

Storek J, Geddes M, Khan F, Huard B, Helg C, Chalandon Y . Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. Semin Immunopathol. 2008; 30(4):425-37. DOI: 10.1007/s00281-008-0132-5. View

Bertuzzi M, Hayes G, Icheoku U, van Rhijn N, Denning D, Osherov N . Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease. J Fungi (Basel). 2018; 4(1). PMC: 5872311. DOI: 10.3390/jof4010008. View

McCoy M, Tansey M . TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation. 2008; 5:45. PMC: 2577641. DOI: 10.1186/1742-2094-5-45. View

Armstrong-James D, Turnbull S, Teo I, Stark J, Rogers N, Rogers T . Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis. 2009; 200(8):1341-51. DOI: 10.1086/605931. View

Shamriz O, Chandrakasan S . Update on Advances in Hematopoietic Cell Transplantation for Primary Immunodeficiency Disorders. Immunol Allergy Clin North Am. 2018; 39(1):113-128. DOI: 10.1016/j.iac.2018.08.003. View

10.

Willment J, Brown G . C-type lectin receptors in antifungal immunity. Trends Microbiol. 2007; 16(1):27-32. DOI: 10.1016/j.tim.2007.10.012. View

11.

Zoran T, Weber M, Springer J, White P, Bauer J, Schober A . Treatment with etanercept and low monocyte concentration contribute to the risk of invasive aspergillosis in patients post allogeneic stem cell transplantation. Sci Rep. 2019; 9(1):17231. PMC: 6872713. DOI: 10.1038/s41598-019-53504-8. View

12.

Stuehler C, Kuenzli E, Jaeger V, Baettig V, Ferracin F, Rajacic Z . Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation and Association With Occurrence and Outcome of Invasive Aspergillosis. J Infect Dis. 2015; 212(6):959-67. DOI: 10.1093/infdis/jiv143. View

13.

Wojtowicz A, Gresnigt M, Lecompte T, Bibert S, Manuel O, Joosten L . IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation. J Infect Dis. 2014; 211(10):1646-57. DOI: 10.1093/infdis/jiu636. View

14.

Tramsen L, Schmidt S, Roeger F, Schubert R, Salzmann-Manrique E, Latge J . Immunosuppressive compounds exhibit particular effects on functional properties of human anti-Aspergillus Th1 cells. Infect Immun. 2014; 82(6):2649-56. PMC: 4019178. DOI: 10.1128/IAI.01700-14. View

15.

Marischen L, Englert A, Schmitt A, Einsele H, Loeffler J . Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus. BMC Immunol. 2018; 19(1):39. PMC: 6299526. DOI: 10.1186/s12865-018-0276-6. View

16.

Cenci E, Mencacci A, Fe dOstiani C, Del Sero G, Mosci P, Montagnoli C . Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis. J Infect Dis. 1998; 178(6):1750-60. DOI: 10.1086/314493. View

17.

Re F, Strominger J . Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem. 2001; 276(40):37692-9. DOI: 10.1074/jbc.M105927200. View

18.

Gupta S, Wang W, Hayek S, Chan L, Mathews K, Melamed M . Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2020; 181(1):41-51. PMC: 7577201. DOI: 10.1001/jamainternmed.2020.6252. View

19.

DIAMOND R, Clark R . Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro. Infect Immun. 1982; 38(2):487-95. PMC: 347765. DOI: 10.1128/iai.38.2.487-495.1982. View

20.

Al-Bader N, Sheppard D . Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies. Virulence. 2016; 7(8):950-966. PMC: 5160406. DOI: 10.1080/21505594.2016.1231278. View