Reconstitution of the Immune System After Hematopoietic Stem Cell Transplantation in Humans

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2008 Oct 25

PMID 18949477

Citations 102

Authors

Jan Storek

Michelle Geddes

Faisal Khan

Bertrand Huard

Claudine Helg

Yves Chalandon

Jakob Passweg

Eddy Roosnek

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.

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