Current Status and New Experimental Diagnostic Methods of Invasive Fungal Infections After Hematopoietic Stem Cell Transplantation

Overview

Journal Arch Microbiol

Specialty Microbiology

Date 2024 Apr 28

PMID 38678508

Authors

Zhenhua Tang

Haitao Wang

Yuankai Liu

Chen Wang

Xinye Li

Qiong Yang

Affiliations

Soon will be listed here.

Abstract

Invasive fungal infections (IFIs) are common and life-threatening complications in post-hematopoietic stem cell transplantation (post-HSCT) recipients, Severe IFIs can lead to systemic infection and organ damage, which results in high mortality in HSCT recipients. With the development of the field of fungal infection diagnosis, more and more advanced non-culture diagnostic tools have been developed, such as glip biosensors, metagenomic next-generation sequencing, Magnetic Nanoparticles and Identified Using SERS via AgNPs , and artificial intelligence-assisted diagnosis. The advanced diagnostic approaches contribute to the success of HSCT and improve the overall survival of post-HSCT leukemia patients by supporting therapeutical decisions. This review provides an overview of the characteristics of two high-incidence IFIs in post-HSCT recipients and discusses some of the recently developed IFI detection technologies. Additionally, it explores the potential application of cationic conjugated polymer fluorescence resonance energy transfer (CCP-FRET) technology for IFI detection. The aim is to offer insights into selecting appropriate IFI detection methods and gaining an understanding of novel fungal diagnostic approaches in laboratory settings.

References

Arvanitis M, Anagnostou T, Fuchs B, Caliendo A, Mylonakis E . Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev. 2014; 27(3):490-526. PMC: 4135902. DOI: 10.1128/CMR.00091-13. View

Bakken I, Jackson C, Utheim T, Villani E, Hamrah P, Kheirkhah A . The use of in vivo confocal microscopy in fungal keratitis - Progress and challenges. Ocul Surf. 2022; 24:103-118. DOI: 10.1016/j.jtos.2022.03.002. View

Benedict K, Jackson B, Chiller T, Beer K . Estimation of Direct Healthcare Costs of Fungal Diseases in the United States. Clin Infect Dis. 2018; 68(11):1791-1797. PMC: 6409199. DOI: 10.1093/cid/ciy776. View

Bhatnagar I, Mahato K, Ealla K, Asthana A, Chandra P . Chitosan stabilized gold nanoparticle mediated self-assembled gliP nanobiosensor for diagnosis of Invasive Aspergillosis. Int J Biol Macromol. 2017; 110:449-456. DOI: 10.1016/j.ijbiomac.2017.12.084. View

Bojang E, Ghuman H, Kumwenda P, Hall R . Immune Sensing of . J Fungi (Basel). 2021; 7(2). PMC: 7914548. DOI: 10.3390/jof7020119. View

Busca A, Cinatti N, Gill J, Passera R, Dellacasa C, Giaccone L . Management of Invasive Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: The Turin Experience. Front Cell Infect Microbiol. 2022; 11:805514. PMC: 8782257. DOI: 10.3389/fcimb.2021.805514. View

Chen X, Xu J, Wu D . Clinical Characteristics and Outcomes of Breakthrough Candidemia in 71 Hematologic Malignancy Patients and/or Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Single-center Retrospective Study From China, 2011-2018. Clin Infect Dis. 2020; 71(Suppl 4):S394-S399. DOI: 10.1093/cid/ciaa1523. View

Yu X, Yan M, Cui Y, Liu Z, Liu H, Zhou J . Effects of Co-application of Cadmium-Immobilizing Bacteria and Organic Fertilizers on and Microbial Communities in a Cadmium-Contaminated Field. Front Microbiol. 2022; 12:809834. PMC: 9122265. DOI: 10.3389/fmicb.2021.809834. View

Choi J, Cho S, Yoon S, Moon J, Kim S, Lee J . Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study. Biol Blood Marrow Transplant. 2017; 23(10):1773-1779. DOI: 10.1016/j.bbmt.2017.06.012. View

10.

Corzo-Leon D, Satlin M, Soave R, Shore T, Schuetz A, Jacobs S . Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single-centre study with focus on emerging pathogens. Mycoses. 2015; 58(6):325-36. DOI: 10.1111/myc.12318. View

11.

Cotten C, McDonald S, Stoll B, Goldberg R, Poole K, Benjamin Jr D . The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006; 118(2):717-22. DOI: 10.1542/peds.2005-2677. View

12.

Duan X, Yue W, Liu L, Li Z, Li Y, He F . Single-nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution. Nat Protoc. 2009; 4(6):984-91. DOI: 10.1038/nprot.2009.70. View

13.

Elfeky R, Lazareva A, Qasim W, Veys P . Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources. Expert Rev Clin Immunol. 2019; 15(7):735-751. DOI: 10.1080/1744666X.2019.1612746. View

14.

Feng F, Wang H, Han L, Wang S . Fluorescent conjugated polyelectrolyte as an indicator for convenient detection of DNA methylation. J Am Chem Soc. 2008; 130(34):11338-43. DOI: 10.1021/ja8011963. View

15.

Feng F, Liu L, Wang S . Fluorescent conjugated polymer-based FRET technique for detection of DNA methylation of cancer cells. Nat Protoc. 2010; 5(7):1255-64. DOI: 10.1038/nprot.2010.79. View

16.

Gardiner D, Howlett B . Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus. FEMS Microbiol Lett. 2005; 248(2):241-8. DOI: 10.1016/j.femsle.2005.05.046. View

17.

Glampedakis E, Cassaing S, Fekkar A, Dannaoui E, Bougnoux M, Bretagne S . Invasive Aspergillosis Due to Aspergillus Section Usti: A Multicenter Retrospective Study. Clin Infect Dis. 2020; 72(8):1379-1385. DOI: 10.1093/cid/ciaa230. View

18.

Gu W, Deng X, Lee M, Sucu Y, Arevalo S, Stryke D . Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids. Nat Med. 2020; 27(1):115-124. PMC: 9020267. DOI: 10.1038/s41591-020-1105-z. View

19.

Guo J, Luo Y, Wu Y, Lai W, Mu X . Clinical Characteristic and Pathogen Spectrum of Neonatal Sepsis in Guangzhou City from June 2011 to June 2017. Med Sci Monit. 2019; 25:2296-2304. PMC: 6451358. DOI: 10.12659/MSM.912375. View

20.

Harrison N, Mitterbauer M, Tobudic S, Kalhs P, Rabitsch W, Greinix H . Incidence and characteristics of invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients: a retrospective cohort study. BMC Infect Dis. 2015; 15:584. PMC: 4696168. DOI: 10.1186/s12879-015-1329-6. View