Characterization of Serum Protein Electrophoresis Patterns and C-reactive Protein in Canine Tick-borne Diseases

Overview

Journal Vet World

Specialty Veterinary Medicine

Date 2021 Sep 27

PMID 34566333

Authors

Sariya Asawakarn

Piyanan Taweethavonsawat

Affiliations

Soon will be listed here.

Abstract

Background And Aim: Canine tick-borne diseases are important diseases with a worldwide distribution. In Thailand, the most important canine tick-borne diseases are ehrlichiosis, babesiosis, and hepatozoonosis. This study aimed to determine the serum protein electrophoresis patterns (SPEPs) and C-reactive protein (CRP) levels associated with , or single infections.

Materials And Methods: A total of 650 canine blood samples were collected from animal hospitals and clinics in Bangkok and its vicinity to examine health status and blood parasite infection. Suspected blood parasite infections were examined by buffy coat thin blood smear and confirmed by polymerase chain reaction. Normal dog and positive , and single infections and serum protein profiles were determined by agarose gel electrophoresis. CRP concentration was measured by fluorescent immunoassay.

Results: In dogs infected with , , and single infections, albumin levels and A/G ratios significantly decreased, whereas β2-globulin levels increased (p<0.05). The γ-globulin level significantly increased in and infections (p<0.05). A monoclonal gammopathy pattern wasi observed in and sngle infections, whereas β-γ bridging patterns and increased β- and γ-globulin fractions were found in single infections. The CRP level increased in dogs with blood parasite single infections and may be related to the pathogenesis of the infection.

Conclusion: SPEPs and CRP levels can be used to monitor health status and blood parasite problems in infected dogs.

Citing Articles

Evaluation of serum protein electrophoresis and immunofixation in dogs seropositive for various vector-borne pathogens.

Jornet-Rius O, Chornarm N, Skeldon N, McGrew A, Lappin M, Solano-Gallego L Vet Clin Pathol. 2024; 53(4):420-430.

PMID: 39528734 PMC: 11735645. DOI: 10.1111/vcp.13399.

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