A Review of Canine Babesiosis: the European Perspective

Overview

Journal Parasit Vectors

Publisher Biomed Central

Specialties Parasitology
Tropical Medicine

Date 2016 Jun 13

PMID 27289223

Citations 126

Authors

Laia Solano-Gallego

Angel Sainz

Xavier Roura

Agustin Estrada-Pena

Guadalupe Miro

Affiliations

Soon will be listed here.

Abstract

Canine babesiosis is a significant tick-borne disease caused by various species of the protozoan genus Babesia. Although it occurs worldwide, data relating to European infections have now been collected for many years. These data have boosted the publication record and increased our working knowledge of these protozoan parasites. Both the large and small forms of Babesia species (B. canis, B. vogeli, B. gibsoni, and B. microti-like isolates also referred to as "B. vulpes" and "Theileria annae") infect dogs in Europe, and their geographical distribution, transmission, clinical signs, treatment, and prognosis vary widely for each species. The goal of this review is to provide veterinary practitioners with practical guidelines for the diagnosis, treatment and prevention of babesiosis in European dogs. Our hope is that these guidelines will answer the most frequently asked questions posed by veterinary practitioners.

Citing Articles

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References

Solano-Gallego L, Trotta M, Carli E, Carcy B, Caldin M, Furlanello T . Babesia canis canis and Babesia canis vogeli clinicopathological findings and DNA detection by means of PCR-RFLP in blood from Italian dogs suspected of tick-borne disease. Vet Parasitol. 2008; 157(3-4):211-21. DOI: 10.1016/j.vetpar.2008.07.024. View

Duh D, Tozon N, Petrovec M, Strasek K, Avsic-Zupanc T . Canine babesiosis in Slovenia: molecular evidence of Babesia canis canis and Babesia canis vogeli. Vet Res. 2004; 35(3):363-8. DOI: 10.1051/vetres:2004018. View

Kubelova M, Sedlak K, Panev A, Siroky P . Conflicting results of serological, PCR and microscopic methods clarify the various risk levels of canine babesiosis in Slovakia: a complex approach to Babesia canis diagnostics. Vet Parasitol. 2012; 191(3-4):353-7. DOI: 10.1016/j.vetpar.2012.09.016. View

Gojska-Zygner O, Zygner W . Hyperaldosteronism and its association with hypotension and azotaemia in canine babesiosis. Vet Q. 2014; 35(1):37-42. DOI: 10.1080/01652176.2014.981765. View

Kjemtrup A, Conrad P . Human babesiosis: an emerging tick-borne disease. Int J Parasitol. 2000; 30(12-13):1323-37. DOI: 10.1016/s0020-7519(00)00137-5. View

Eichenberger R, Riond B, Willi B, Hofmann-Lehmann R, Deplazes P . Prognostic Markers in Acute Babesia canis Infections. J Vet Intern Med. 2016; 30(1):174-82. PMC: 4913656. DOI: 10.1111/jvim.13822. View

Irwin P, Hutchinson G . Clinical and pathological findings of Babesia infection in dogs. Aust Vet J. 1991; 68(6):204-9. DOI: 10.1111/j.1751-0813.1991.tb03194.x. View

Duscher G, Fuehrer H, Kubber-Heiss A . Fox on the run--molecular surveillance of fox blood and tissue for the occurrence of tick-borne pathogens in Austria. Parasit Vectors. 2014; 7:521. PMC: 4243377. DOI: 10.1186/s13071-014-0521-7. View

Camacho A, Guitian F, Pallas E, Gestal J, Olmeda S, Goethert H . Serum protein response and renal failure in canine Babesia annae infection. Vet Res. 2005; 36(5-6):713-22. DOI: 10.1051/vetres:2005026. View

10.

Falkeno U, Tasker S, Osterman-Lind E, Tvedten H . Theileria annae in a young Swedish dog. Acta Vet Scand. 2013; 55:50. PMC: 3723473. DOI: 10.1186/1751-0147-55-50. View

11.

Martinod S, Brossard M, Moreau Y . Immunity of dogs against Babesia canis, its vector tick Dermacentor reticulatus, and Ixodes ricinus in endemic area. J Parasitol. 1985; 71(3):269-73. View

12.

Kidd L, Mackman N . Prothrombotic mechanisms and anticoagulant therapy in dogs with immune-mediated hemolytic anemia. J Vet Emerg Crit Care (San Antonio). 2013; 23(1):3-13. DOI: 10.1111/j.1476-4431.2012.00824.x. View

13.

Solano-Gallego L, Baneth G . Babesiosis in dogs and cats--expanding parasitological and clinical spectra. Vet Parasitol. 2011; 181(1):48-60. DOI: 10.1016/j.vetpar.2011.04.023. View

14.

Rosa C, Pazzi P, Nagel S, McClure V, Christie J, Troskie M . Theileriosis in six dogs in South Africa and its potential clinical significance. J S Afr Vet Assoc. 2015; 85(1):1114. DOI: 10.4102/jsava.v85i1.1114. View

15.

Carret C, Walas F, Carcy B, Grande N, Precigout E, Moubri K . Babesia canis canis, Babesia canis vogeli, Babesia canis rossi: differentiation of the three subspecies by a restriction fragment length polymorphism analysis on amplified small subunit ribosomal RNA genes. J Eukaryot Microbiol. 1999; 46(3):298-303. DOI: 10.1111/j.1550-7408.1999.tb05128.x. View

16.

Jacobson L, Reyers F, Berry W, Viljoen E . Changes in haematocrit after treatment of uncomplicated canine babesiosis: a comparison between diminazene and trypan blue, and an evaluation of the influence of parasitaemia. J S Afr Vet Assoc. 1996; 67(2):77-82. View

17.

Hodzic A, Alic A, Fuehrer H, Harl J, Wille-Piazzai W, Duscher G . A molecular survey of vector-borne pathogens in red foxes (Vulpes vulpes) from Bosnia and Herzegovina. Parasit Vectors. 2015; 8:88. PMC: 4367825. DOI: 10.1186/s13071-015-0692-x. View

18.

Carret C, Delbecq S, Labesse G, Carcy B, Precigout E, Moubri K . Characterization and molecular cloning of an adenosine kinase from Babesia canis rossi. Eur J Biochem. 1999; 265(3):1015-21. DOI: 10.1046/j.1432-1327.1999.00806.x. View

19.

Duscher G, Feiler A, Leschnik M, Joachim A . Seasonal and spatial distribution of ixodid tick species feeding on naturally infested dogs from Eastern Austria and the influence of acaricides/repellents on these parameters. Parasit Vectors. 2013; 6:76. PMC: 3621693. DOI: 10.1186/1756-3305-6-76. View

20.

Aktas M, Ozubek S, Altay K, Ipek N, Balkaya I, Utuk A . Molecular detection of tick-borne rickettsial and protozoan pathogens in domestic dogs from Turkey. Parasit Vectors. 2015; 8:157. PMC: 4364499. DOI: 10.1186/s13071-015-0763-z. View