Canine Babesiosis: a Perspective on Clinical Complications, Biomarkers, and Treatment

Overview

Journal Vet Med (Auckl)

Specialty Veterinary Medicine

Date 2018 Aug 30

PMID 30155438

Citations 25

Authors

Liza S Koster

Remo G Lobetti

Patrick Kelly

Affiliations

Soon will be listed here.

Abstract

Canine babesiosis is a common tick transmitted disease of dogs worldwide. A number of sp. can infect dogs and the spectrum is increasing as molecular methods are developed to differentiate organisms. Clinical signs are generally attributed to hemolysis caused by the organisms in the erythrocytes but in some animals with some spp. there can be an immune mediated component to the anemia and/or a severe inflammatory reaction associated. This complicated form of canine babesiosis is associated with high morbidity and mortality. A variety of clinical markers has been investigated to enable clinicians to provide more accurate prognoses and adapt their treatments which vary according to the infecting species. In this review, we discuss the taxonomy, clinical signs, diagnostic imaging, clinical biomarkers, treatment, and prophylaxis of one of the most common and important diseases of dogs worldwide.

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References

Irwin P, Hutchinson G . Clinical and pathological findings of Babesia infection in dogs. Aust Vet J. 1991; 68(6):204-9. DOI: 10.1111/j.1751-0813.1991.tb03194.x. View

Schoeman J, Rees P, Herrtage M . Endocrine predictors of mortality in canine babesiosis caused by Babesia canis rossi. Vet Parasitol. 2007; 148(2):75-82. DOI: 10.1016/j.vetpar.2007.06.010. View

Solano-Gallego L, Baneth G . Babesiosis in dogs and cats--expanding parasitological and clinical spectra. Vet Parasitol. 2011; 181(1):48-60. DOI: 10.1016/j.vetpar.2011.04.023. View

Lobetti R, Reyers F . Met-haemoglobinuria in naturally occurring Babesia canis infection. J S Afr Vet Assoc. 1996; 67(2):88-90. View

Lobetti R . Changes in the serum urea: creatinine ratio in dogs with babesiosis, haemolytic anaemia, and experimental haemoglobinaemia. Vet J. 2011; 191(2):253-6. DOI: 10.1016/j.tvjl.2011.01.027. View

Boozer A, Macintire D . Canine babesiosis. Vet Clin North Am Small Anim Pract. 2003; 33(4):885-904, viii. DOI: 10.1016/s0195-5616(03)00039-1. View

Furlanello T, Fiorio F, Caldin M, Lubas G, Solano-Gallego L . Clinicopathological findings in naturally occurring cases of babesiosis caused by large form Babesia from dogs of northeastern Italy. Vet Parasitol. 2005; 134(1-2):77-85. DOI: 10.1016/j.vetpar.2005.07.016. View

Kjemtrup A, Wainwright K, Miller M, Penzhorn B, Carreno R . Babesia conradae, sp. Nov., a small canine Babesia identified in California. Vet Parasitol. 2006; 138(1-2):103-11. DOI: 10.1016/j.vetpar.2006.01.044. View

Collett M . Survey of canine babesiosis in South Africa. J S Afr Vet Assoc. 2001; 71(3):180-6. DOI: 10.4102/jsava.v71i3.710. View

10.

Scheepers E, Leisewitz A, Thompson P, Christopher M . Serial haematology results in transfused and non-transfused dogs naturally infected with Babesia rossi. J S Afr Vet Assoc. 2012; 82(3):136-43. DOI: 10.4102/jsava.v82i3.51. View

11.

Irwin P . Canine babesiosis: from molecular taxonomy to control. Parasit Vectors. 2009; 2 Suppl 1:S4. PMC: 2679396. DOI: 10.1186/1756-3305-2-S1-S4. View

12.

Tasaki Y, Miura N, Iyori K, Nishifuji K, Endo Y, Momoi Y . Generalized alopecia with vasculitis-like changes in a dog with babesiosis. J Vet Med Sci. 2013; 75(10):1367-9. PMC: 3942935. DOI: 10.1292/jvms.12-0482. View

13.

de Scally M, Lobetti R, Reyers F, Humphris D . Are urea and creatinine values reliable indicators of azotaemia in canine babesiosis?. J S Afr Vet Assoc. 2005; 75(3):121-4. DOI: 10.4102/jsava.v75i3.466. View

14.

Miller D, Swan G, Lobetti R, Jacobson L . The pharmacokinetics of diminazene aceturate after intramuscular administration in healthy dogs. J S Afr Vet Assoc. 2005; 76(3):146-50. DOI: 10.4102/jsava.v76i3.416. View

15.

Jacobson L, Clark I . The pathophysiology of canine babesiosis: new approaches to an old puzzle. J S Afr Vet Assoc. 1994; 65(3):134-45. View

16.

Schnittger L, Rodriguez A, Florin-Christensen M, Morrison D . Babesia: a world emerging. Infect Genet Evol. 2012; 12(8):1788-809. DOI: 10.1016/j.meegid.2012.07.004. View

17.

Matijatko V, Kis I, Torti M, Brkljacic M, Kucer N, Baric Rafaj R . Septic shock in canine babesiosis. Vet Parasitol. 2009; 162(3-4):263-70. DOI: 10.1016/j.vetpar.2009.03.011. View

18.

Sweers L, Kirberger R, Leisewitz A, Dormehl I, Killian E, Naude F . The scintigraphic evaluation of the pulmonary perfusion pattern of dogs hospitalised with babesiosis. J S Afr Vet Assoc. 2008; 79(2):76-83. DOI: 10.4102/jsava.v79i2.248. View

19.

Nel M, Lobetti R, Keller N, Thompson P . Prognostic value of blood lactate, blood glucose, and hematocrit in canine babesiosis. J Vet Intern Med. 2004; 18(4):471-6. DOI: 10.1892/0891-6640(2004)18<471:pvoblb>2.0.co;2. View

20.

Lobetti R, Mohr A, Dippenaar T, Myburgh E . A preliminary study on the serum protein response in canine babesiosis. J S Afr Vet Assoc. 2000; 71(1):38-42. DOI: 10.4102/jsava.v71i1.675. View