Improved Post-stroke Spontaneous Recovery by Astrocytic Extracellular Vesicles

Overview

Journal Mol Ther

Publisher Cell Press

Specialties Molecular Biology
Pharmacology

Date 2021 Sep 26

PMID 34563674

Citations 16

Authors

Yessica Heras-Romero

Axayacatl Morales-Guadarrama

Ricardo Santana-Martinez

Isaac Ponce

Ruth Rincon-Heredia

Augusto Cesar Poot-Hernandez

Araceli Martinez-Moreno

Esteban Urrieta

Berenice N Bernal-Vicente

Aura N Campero-Romero

Perla Moreno-Castilla

Nigel H Greig

Martha L Escobar

Luis Concha

Luis B Tovar-y-Romo

Affiliations

Soon will be listed here.

Abstract

Spontaneous recovery after a stroke accounts for a significant part of the neurological recovery in patients. However limited, the spontaneous recovery is mechanistically driven by axonal restorative processes for which several molecular cues have been previously described. We report the acceleration of spontaneous recovery in a preclinical model of ischemia/reperfusion in rats via a single intracerebroventricular administration of extracellular vesicles released from primary cortical astrocytes. We used magnetic resonance imaging and confocal and multiphoton microscopy to correlate the structural remodeling of the corpus callosum and striatocortical circuits with neurological performance during 21 days. We also evaluated the functionality of the corpus callosum by repetitive recordings of compound action potentials to show that the recovery facilitated by astrocytic extracellular vesicles was both anatomical and functional. Our data provide compelling evidence that astrocytes can hasten the basal recovery that naturally occurs post-stroke through the release of cellular mediators contained in extracellular vesicles.

Citing Articles

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Synaptotagmin 4 Supports Spontaneous Axon Sprouting after Spinal Cord Injury.

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Xie Y, Deng T, Xie L, Xie Y, Ma J, Zhong D Exp Ther Med. 2024; 28(1):287.

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