Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2021 Sep 20

PMID 34543425

Citations 6

Authors

Cora M Best

Leila R Zelnick

Kenneth E Thummel

Simon Hsu

Christine Limonte

Ravi Thadhani

Howard D Sesso

JoAnn E Manson

Julie E Buring

Samia Mora

I-Min Lee

Nancy R Cook

Georgina Friedenberg

Heike Luttmann-Gibson

Ian H de Boer

Andrew N Hoofnagle

Affiliations

Soon will be listed here.

Abstract

Context: The effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition.

Objective: To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D [25(OH)D], which is used clinically and measured in supplementation trials.

Design: Exploratory study within a randomized trial.

Intervention: 2000 International Units of vitamin D3 per day (or matching placebo).

Setting: Community-based.

Participants: 161 adults (mean ± SD age 70 ± 6 years; 66% males) with type 2 diabetes.

Main Outcome Measures: Changes in total serum vitamin D and total serum 25(OH)D concentrations from baseline to year 2.

Results: At baseline, there was a positive, nonlinear relation between total serum vitamin D and total serum 25(OH)D concentrations. Adjusted effects of supplementation were a 29.2 (95% CI: 24.3, 34.1) nmol/L increase in serum vitamin D and a 33.4 (95% CI: 27.7, 39.2) nmol/L increase in serum 25(OH)D. Among those with baseline 25(OH)D < 50 compared with ≥ 50 nmol/L, the serum vitamin D response to supplementation was attenuated (15.7 vs 31.2 nmol/L; interaction P-value = 0.02), whereas the serum 25(OH)D response was augmented (47.9 vs 30.7 nmol/L; interaction P-value = 0.05).

Conclusions: Vitamin D3 supplementation increases total serum vitamin D and 25(OH)D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D3 is more efficient when serum 25(OH)D concentration is low.

Citing Articles

Vitamin D Supplementation: Shedding Light on the Role of the Sunshine Vitamin in the Prevention and Management of Type 2 Diabetes and Its Complications.

Vasdeki D, Tsamos G, Dimakakos E, Patriarcheas V, Koufakis T, Kotsa K Nutrients. 2024; 16(21).

PMID: 39519484 PMC: 11547801. DOI: 10.3390/nu16213651.

Multifaceted Roles of Vitamin D for Diabetes: From Immunomodulatory Functions to Metabolic Regulations.

Park C, Shin S, Han S Nutrients. 2024; 16(18).

PMID: 39339785 PMC: 11435169. DOI: 10.3390/nu16183185.

Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.

Gomez O, Campusano C, Cerdas-P S, Mendoza B, Paez-Talero A, de la Pena-Rodriguez M Arch Osteoporos. 2024; 19(1):46.

PMID: 38850469 PMC: 11162390. DOI: 10.1007/s11657-024-01398-z.

A Fracture Liaison Service to Address Vitamin D Deficiency for Patients Hospitalized for Osteoporotic Fracture.

Sun X, Leder B, Bolster M, Ly T, Franco-Garcia E, Pu C J Endocr Soc. 2024; 8(5):bvae050.

PMID: 38550278 PMC: 10977957. DOI: 10.1210/jendso/bvae050.

Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis.

van den Heuvel E, Lips P, Schoonmade L, Lanham-New S, van Schoor N Adv Nutr. 2023; 15(1):100133.

PMID: 37865222 PMC: 10831883. DOI: 10.1016/j.advnut.2023.09.016.

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