Common Genetic Variants of the Vitamin D Binding Protein (DBP) Predict Differences in Response of Serum 25-hydroxyvitamin D [25(OH)D] to Vitamin D Supplementation

Overview

Journal Clin Biochem

Specialty Biochemistry

Date 2009 Mar 24

PMID 19302999

Citations 90

Authors

Lei Fu

Francisco Yun

Marko Oczak

Betty Y L Wong

Reinhold Vieth

David E C Cole

Affiliations

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Abstract

Background: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.

Methods: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: Mean 25(OH)D increases were 97% for TT (n=48), 151% for TK (n=31) and 307% (n=6) for KK genotypes (p=.004).

Conclusions: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.

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