Betaine, a Component of , Enhances Muscular Endurance of Mice and Myogenesis of Myoblasts

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2021 Sep 17

PMID 34532017

Citations 3

Authors

Sang-Soo Lee

Yong-An Kim

Bokkee Eun

Jayeon Yoo

Eun-Mi Kim

Myoung Soo Nam

Kee K Kim

Affiliations

Soon will be listed here.

Abstract

Sarcopenia is a disease characterized by the loss of muscle mass and function that occurs mainly in older adults. The present study was designed to investigate the hypothesis that water extract of (WELC) would improve muscle function and promote myogenesis for sarcopenia. We investigated the effect of water extracts of . on muscular endurance function and myogenesis to examine its efficacy in sarcopenia. Intake of WELC-containing cheese enhanced the muscular endurance function of mice in treadmill endurance tests. In addition, the cross-sectional areas of muscle fibers in the gastrocnemius muscle of . -fed mice were greater than that of control mice. Furthermore, WELC and its key component marker substance betaine promoted myogenesis of myoblasts by increasing the expression of the myogenic protein myosin heavy chain 3 (Myh3) and myotube formation. Taken together, our results suggest that . may potentially be useful in the development of preventive and therapeutic agents for sarcopenia, as well as in providing basic knowledge on myogenesis and muscular functions.

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Betaine, a component of , enhances muscular endurance of mice and myogenesis of myoblasts.

Lee S, Kim Y, Eun B, Yoo J, Kim E, Nam M Food Sci Nutr. 2021; 9(9):5083-5091.

PMID: 34532017 PMC: 8441376. DOI: 10.1002/fsn3.2466.

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