Recovering Genotypes and Phenotypes Using Allele-specific Genes

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2021 Sep 8

PMID 34493313

Citations 6

Authors

Gamze Gursoy

Nancy Lu

Sarah Wagner

Mark Gerstein

Affiliations

Soon will be listed here.

Abstract

With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum.

Citing Articles

Secure and federated quantitative trait loci mapping with privateQTL.

Choi Y, Kim Y, Miao P, Lappalainen T, Gursoy G Cell Genom. 2025; 5(2):100769.

PMID: 39947138 PMC: 11872535. DOI: 10.1016/j.xgen.2025.100769.

Private information leakage from single-cell count matrices.

Walker C, Li X, Chakravarthy M, Lounsbery-Scaife W, Choi Y, Singh R Cell. 2024; 187(23):6537-6549.e10.

PMID: 39362221 PMC: 11568916. DOI: 10.1016/j.cell.2024.09.012.

Assessing Privacy Vulnerabilities in Genetic Data Sets: Scoping Review.

Thomas M, Mackes N, Preuss-Dodhy A, Wieland T, Bundschus M JMIR Bioinform Biotechnol. 2024; 5:e54332.

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Assessing transcriptomic reidentification risks using discriminative sequence models.

Sadhuka S, Fridman D, Berger B, Cho H Genome Res. 2023; 33(7):1101-1112.

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Privacy-aware estimation of relatedness in admixed populations.

Wang S, Kim M, Li W, Jiang X, Chen H, Harmanci A Brief Bioinform. 2022; 23(6).

PMID: 36384083 PMC: 10144692. DOI: 10.1093/bib/bbac473.

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