Effects of Nelumbo Nucifera Leaf Extract on Obesity

Overview

Journal Plant Foods Hum Nutr

Specialties Biology
Nutritional Sciences

Date 2021 Aug 31

PMID 34462872

Citations 3

Authors

Enuo Liu

Hiroshi Tsuboi

Shuuji Ikegami

Tomonori Kamiyama

Yukio Asami

Luyi Ye

Munehiro Oda

Zai-Si Ji

Affiliations

Soon will be listed here.

Abstract

The two main components from a Nelumbo nucifera leaf extract (NnEx) were investigated for their ability to prevent triglyceride accumulation and promoting lipolysis. Sun-dried Nelumbo nucifera leaves were immersed in hot water to extract the soluble components, and the resulting solution was analyzed by LC-MS and nuclear magnetic resonance. The results showed that quercetin-3-O-ß-glucuronide (Q3GA) and quercetin were the key components of the NnEx. In vitro experiments confirmed that quercetin and Q3GA functioned in lipid metabolism by promoting triglyceride degradation through inhibition of the cAMP pathway. In vivo experiments showed that NnEx ingestion inhibited the accumulation of neutral fats in ICR mice and transitioned the hepatocytes of type II diabetic KK-Ay mice out of glycogenosis. These results highlight the ability of NnEx to control metabolism by modulating fat and sugar absorption and may provide an interesting novel treatment for obesity and related lifestyle diseases such as type II diabetes.

Citing Articles

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