Association Between Gut Microbiota and Development of Gestational Diabetes Mellitus

Overview

Journal Microorganisms

Specialty Microbiology

Date 2021 Aug 27

PMID 34442765

Citations 16

Authors

Palin Sililas

Lingling Huang

Chanisa Thonusin

Suchaya Luewan

Nipon Chattipakorn

Siriporn Chattipakorn

Theera Tongsong

Affiliations

Soon will be listed here.

Abstract

It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). : Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24-28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed.

Citing Articles

The Impact of Gestational Diabetes Mellitus (GDM) on the Development and Composition of the Neonatal Gut Microbiota: A Systematic Review.

Sokou R, Moschari E, Palioura A, Palioura A, Mpakosi A, Adamakidou T Microorganisms. 2024; 12(8).

PMID: 39203408 PMC: 11356352. DOI: 10.3390/microorganisms12081564.

Gestational diabetes mellitus: Impacts on fetal neurodevelopment, gut dysbiosis, and the promise of precision medicine.

Biete M, Vasudevan S Front Mol Biosci. 2024; 11:1420664.

PMID: 39055983 PMC: 11269231. DOI: 10.3389/fmolb.2024.1420664.

Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies.

Xiao L, Zuo Z, Zhao F Genomics Proteomics Bioinformatics. 2024; 22(1).

PMID: 38862423 PMC: 11104452. DOI: 10.1093/gpbjnl/qzad005.

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.

Lu X, Shi Z, Jiang L, Zhang S Front Immunol. 2024; 15:1362784.

PMID: 38545107 PMC: 10965710. DOI: 10.3389/fimmu.2024.1362784.

The impact of gut microbiota on autoimmune thyroiditis and relationship with pregnancy outcomes: a review.

Song Y, Bai Y, Liu C, Zhai X, Zhang L Front Cell Infect Microbiol. 2024; 14:1361660.

PMID: 38505287 PMC: 10948601. DOI: 10.3389/fcimb.2024.1361660.

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