MG TRNA Modification Reveals New Secrets in the Translational Regulation of Cancer Development

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2021 Aug 20

PMID 34416137

Citations 38

Authors

Olga Katsara

Robert J Schneider

Affiliations

Soon will be listed here.

Abstract

Orellana et al. (2021) and Dai et al. (2021) demonstrate that increased mG modification of a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay, increases translation efficiency, reduces ribosome pausing, is associated with poor survival in human cancers, and is directly transforming.

Citing Articles

Integrative machine learning model of RNA modifications predict prognosis and treatment response in patients with breast cancer.

Wang T, Wang S, Li Z, Xie J, Jia Q, Hou J Cancer Cell Int. 2025; 25(1):43.

PMID: 39948551 PMC: 11827143. DOI: 10.1186/s12935-025-03651-y.

N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential.

Wu Q, Fu X, Liu G, He X, Li Y, Ou C J Hematol Oncol. 2025; 18(1):12.

PMID: 39881381 PMC: 11780989. DOI: 10.1186/s13045-025-01665-7.

Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases.

Zhou W, Yi Y, Cao W, Zhong X, Chen L Front Pharmacol. 2025; 15():1491763.

PMID: 39850560 PMC: 11754259. DOI: 10.3389/fphar.2024.1491763.

RNA modifications in cancer.

Wu H, Chen S, Li X, Li Y, Shi H, Qing Y MedComm (2020). 2025; 6(1):e70042.

PMID: 39802639 PMC: 11718328. DOI: 10.1002/mco2.70042.

m7GRegpred: substrate prediction of N7-methylguanosine (m7G) writers and readers based on sequencing features.

Zheng Y, Li H, Lin S Front Genet. 2024; 15:1469011.

PMID: 39262420 PMC: 11387174. DOI: 10.3389/fgene.2024.1469011.

References

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