Biological Roles of RNA M7G Modification and Its Implications in Cancer

Overview

Journal Biol Direct

Publisher Biomed Central

Specialty Biology

Date 2023 Sep 14

PMID 37710294

Authors

Xin Zhang

Wen-Yan Zhu

Shu-Yi Shen

Jia-Hao Shen

Xiao-Dong Chen

Affiliations

Soon will be listed here.

Abstract

M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. In addition, there is growing evidence that m7G modifications are crucial in the emergence of cancer. Here, we review the most recent findings regarding the detection techniques, distribution, biological functions and Regulators of m7G. We also summarize the connections between m7G modifications and cancer development, drug resistance, and tumor microenvironment as well as we discuss the research's future directions and trends.

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