Comparison of QSOFA and Hospital Early Warning Scores for Prognosis in Suspected Sepsis in Emergency Department Patients: a Systematic Review

Background: Sepsis is a major cause of morbidity and mortality and many tools exist to facilitate early recognition. This review compares two tools: the quick Sequential Organ Failure Assessment (qSOFA) and Early Warning Scores (National/Modified Early Warning Scores (NEWS/MEWS)) for predicting intensive care unit (ICU) admission and mortality when applied in the emergency department.

Methods: A literature search was conducted using Medline, CINAHL, Embase and Cochrane Library, handsearching of references and a grey literature search with no language or date restrictions. Two authors selected studies and quality assessment completed using QUADAS-2. Area under the receiver operating characteristic curve (AUROC), sensitivities and specificities were compared.

Results: 13 studies were included, totalling 403 865 patients. All reported mortality and six reported ICU admission.The ranges for AUROC estimates varied from little better than chance to good prediction of mortality (NEWS: 0.59-0.88; qSOFA: 0.57-0.79; MEWS 0.56-0.75), however, individual papers generally reported higher AUROC values for NEWS than qSOFA. NEWS values demonstrated a tendency towards better sensitivity for ICU admission (NEWS ≥5, 46%-91%; qSOFA ≥2, 12%-53%) and mortality (NEWS ≥5, 51%-97%; qSOFA ≥2, 14%-71%) but lower specificity (ICU: NEWS ≥5, 25%-91%; qSOFA ≥2, 67%-99%; mortality: NEWS ≥5, 22%-91%; qSOFA ≥2, 58%-99%).

Conclusion: The wide range of AUROC estimates and high heterogeneity limit our conclusions. Allowing for this, the NEWS AUROC was consistently higher than qSOFA within individual papers. Both scores allow threshold setting, determined by the preferred compromise between sensitivity and specificity. At established thresholds NEWS tended to higher sensitivity while qSOFA tended to a higher specificity.

Prospero Registration Number: CRD42019131414.