Potential Usefulness of Enamel Matrix Derivative in Skin and Mucosal Injury Treatment

Overview

Journal Postepy Dermatol Alergol

Publisher Termedia

Specialty Allergy & Immunology

Date 2021 Aug 11

PMID 34377112

Citations 1

Authors

Sylwia Klewin-Steinbock

Zygmunt Adamski

Marzena Wyganowska-Swiatkowska

Affiliations

Soon will be listed here.

Abstract

Enamel matrix proteins (EMP) are secreted by ameloblasts during odontogenesis. The main component of enamel protein extract is amelogenin. The extracts also contain proteins with bioactive properties similar to bone morphogenic proteins and transforming growth factor β1. Research on animal models indicates that EMP improve healing of oral mucosa wounds by stimulating the production of collagen fibers and blood vessels in the connective tissue. Success in the treatment of oral wounds prompted interest in possible applications of amelogenins in the repair of damaged skin due to similarities in histological structure between skin and mucosa.

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