First Survey of SNPs in , , and Genes in Sheep Reared in Italy and Their Association with Resistance to SRLVs Infection

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Aug 10

PMID 34372496

Citations 10

Authors

Chiara Arcangeli

Daniele Lucarelli

Martina Torricelli

Carla Sebastiani

Marcella Ciullo

Claudia Pellegrini

Andrea Felici

Silva Costarelli

Monica Giammarioli

Francesco Feliziani

Fabrizio Passamonti

Massimo Biagetti

Affiliations

Soon will be listed here.

Abstract

virus (MVV) and caprine arthritis encephalitis virus (CAEV), referred to as small ruminant lentiviruses (SRLVs), belong to the genus of the Retroviridae family. SRLVs infect both sheep and goats, causing significant economic losses and animal welfare damage. Recent findings suggest an association between serological status and allelic variants of different genes such as , , and . The aim of this work was to investigate the role of specific polymorphisms of these genes in SRLVs infection in some sheep flocks in Italy. In addition to those already known, novel variants in the (P7H, I74V, I105V) gene were detected in this study. The risk of infection was determined finding an association between the serological status and polymorphisms P7H, E35K, N70I, I74V, I105V of , R447Q, A462S and G520R in gene, H176H* and K190K* in genes, while no statistical association was observed for the 4-bp deletion of the gene. Since no vaccines or treatments have been developed, a genetically based approach could be an innovative strategy to prevent and to control SRLVs infection. Our findings are an important starting point in order to define the genetic resistance profile towards SRLVs infection.

Citing Articles

First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status.

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Molecular Characterization of Small Ruminant Lentiviruses in Sheep and Goats: A Systematic Review.

Gobbi P, Pavone S, Orso M, Passamonti F, Righi C, Beato M Animals (Basel). 2024; 14(23).

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Identification of New Single Nucleotide Polymorphisms Potentially Related to Small Ruminant Lentivirus Infection Susceptibility in Goats Based on Data Selected from High-Throughput Sequencing.

Materniak-Kornas M, Ropka-Molik K, Piorkowska K, Kowalik J, Szmatola T, Sikora J Pathogens. 2024; 13(10).

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A high-density genome-wide approach reveals novel genetic markers linked to small ruminant lentivirus susceptibility in sheep.

Riggio S, Tolone M, Sottile G, Tumino S, Portolano B, Sutera A Front Genet. 2024; 15:1376883.

PMID: 38911298 PMC: 11191640. DOI: 10.3389/fgene.2024.1376883.

Detection and Phylogenetic Analysis of Caprine Arthritis Encephalitis Virus Using TaqMan-based qPCR in Eastern China.

Tian Y, Zhang H, Zhang Y, Zhang X, Guan Z, Zhang J Vet Sci. 2024; 11(3).

PMID: 38535872 PMC: 10975075. DOI: 10.3390/vetsci11030138.

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