Targeting Mitochondrial Biogenesis with Polyphenol Compounds

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2021 Aug 2

PMID 34336094

Citations 64

Authors

Leila Chodari

Mutlu Dilsiz Aytemir

Parviz Vahedi

Mahdieh Alipour

Sepideh Zununi Vahed

Seyed Mahdi Hosseiniyan Khatibi

Elham Ahmadian

Mohammadreza Ardalan

Aziz Eftekhari

Affiliations

Soon will be listed here.

Abstract

Appropriate mitochondrial physiology is an essential for health and survival. Cells have developed unique mechanisms to adapt to stress circumstances and changes in metabolic demands, by meditating mitochondrial function and number. In this context, sufficient mitochondrial biogenesis is necessary for efficient cell function and haemostasis, which is dependent on the regulation of ATP generation and maintenance of mitochondrial DNA (mtDNA). These procedures play a primary role in the processes of inflammation, aging, cancer, metabolic diseases, and neurodegeneration. Polyphenols have been considered as the main components of plants, fruits, and natural extracts with proven therapeutic effects during the time. These components regulate the intracellular pathways of mitochondrial biogenesis. Therefore, the current review is aimed at representing an updated review which determines the effects of different natural polyphenol compounds from various plant kingdoms on modulating signaling pathways of mitochondrial biogenesis that could be a promising alternative for the treatment of several disorders.

Citing Articles

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