Study of the Antimalarial Activity of the Leaf Extracts and Fractions of and and Their HPLC Analysis

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2021 Aug 2

PMID 34335810

Citations 5

Authors

Philip F Uzor

Chukwuebuka K Onyishi

Adaeze P Omaliko

Somtochukwu A Nworgu

Onyemaechi H Ugwu

Ngozi J Nwodo

Affiliations

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Abstract

In the present study, the antimalarial activity of the extracts and fractions of the leaves of and as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of and demonstrated significant ( < 0.05) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that and possess promising antimalarial activity and they are potential sources of new lead compounds against malaria.

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