Dynamic Functional Connectivity Changes in the Triple Networks and Its Association with Cognitive Impairment in Hemodialysis Patients

Overview

Journal Brain Behav

Specialty Psychology

Date 2021 Aug 1

PMID 34333874

Citations 4

Authors

Jianghui Cao

Guangzhi Liu

Xuekun Li

Zheng Yue

Jipeng Ren

Wei Zhu

Baolin Wu

Affiliations

Soon will be listed here.

Abstract

Introduction: Cognitive impairment is common in hemodialysis (HD) patients; however, the underlying mechanisms have not been fully understood. The "triple-network model" that consists of the salience network (SN), central executive network (CEN), and default mode network (DMN) has been suggested to play an important role in various cognitive functions. However, dynamic functional connectivity (FC) alterations within the triple networks have not been investigated in HD patients.

Methods: Sixty-six HD patients and 66 healthy controls (HCs) were included in this study. The triple networks were identified using a group spatial independent component analysis, and dynamic FC was analyzed using a sliding window approach and k-means clustering algorithm. Furthermore, we analyzed the relationships between altered dynamic FC parameters and clinical variables in HD patients.

Results: The intrinsic brain FC within the triple networks was clustered into four configuration states. Compared with HCs, HD patients spent more time in State 1, which was characterized by weak connections between the DMN and CEN and SN. HD patients showed lower number of transitions across different states than HCs. Moreover, the number of transitions and mean dwell time in State 1 were associated with cognitive performance in HD patients.

Conclusion: Our findings suggest abnormal dynamic FC properties within the triple networks in HD patients, which may provide new insights into the pathophysiological mechanisms of their cognitive deficits from the perspective of dynamic FC.

Citing Articles

Cognitive impairment assessed by static and dynamic changes of spontaneous brain activity during end stage renal disease patients on early hemodialysis.

Wu Y, Li R, Jiang G, Yang N, Liu M, Chen Y Front Neurol. 2025; 16:1510321.

PMID: 40040917 PMC: 11877905. DOI: 10.3389/fneur.2025.1510321.

Abnormal dynamic functional connectivity in young nondisabling intracerebral hemorrhage patients.

Yang D, Luo X, Sun S, Zhang X, Zhang F, Zhao X Ann Clin Transl Neurol. 2024; 11(6):1567-1578.

PMID: 38725138 PMC: 11187952. DOI: 10.1002/acn3.52074.

Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease.

Fang J, Miao Y, Zou F, Liu Y, Zuo J, Qi X Ren Fail. 2023; 45(1):2238829.

PMID: 37488933 PMC: 10392254. DOI: 10.1080/0886022X.2023.2238829.

Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease.

Li X, Yan R, Yue Z, Zhang M, Ren J, Wu B Front Neurosci. 2022; 16:852822.

PMID: 35669490 PMC: 9163405. DOI: 10.3389/fnins.2022.852822.

Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients.

Cao J, Liu G, Li X, Yue Z, Ren J, Zhu W Brain Behav. 2021; 11(8):e2314.

PMID: 34333874 PMC: 8413764. DOI: 10.1002/brb3.2314.

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