Cellular Senescence As a Possible Link Between Prostate Diseases of the Ageing Male

Overview

Journal Nat Rev Urol

Specialty Urology

Date 2021 Jul 23

PMID 34294916

Citations 22

Authors

Gaelle Fiard

Vasilis Stavrinides

Emma S Chambers

Susan Heavey

Alex Freeman

Rhys Ball

Arne N Akbar

Mark Emberton

Affiliations

Soon will be listed here.

Abstract

Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome - known as the senescence-associated secretory phenotype - is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the senescence-associated secretory phenotype and can be linked to BPH and prostate cancer. Indeed, a number of signalling pathways provide biological plausibility for the role of senescence in both BPH and prostate cancer, although proving causality is difficult. The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.

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