Autophagy in Benign Prostatic Hyperplasia: Insights and Therapeutic Potential

Overview

Journal BMC Urol

Publisher Biomed Central

Specialty Urology

Date 2024 Sep 11

PMID 39261818

Authors

Xian-Zhao Zhou

Pei Huang

Yao-Kan Wu

Jin-Ben Yu

Jie Sun

Affiliations

Soon will be listed here.

Abstract

Autophagy is a cellular homeostatic mechanism characterized by cyclic degradation. It plays an essential role in maintaining cellular quality and survival by eliminating dysfunctional cellular components. This process is pivotal in various pathophysiological processes. Benign prostatic hyperplasia (BPH) is a common urological disorder in middle-aged and elderly men. It frequently presents as lower urinary tract symptoms due to an increase in epithelial and stromal cells surrounding the prostatic urethra. The precise pathogenesis of BPH is complex. In recent years, research on autophagy in BPH has gained significant momentum, with accumulating evidence indicating its crucial role in the onset and progression of the disease. This review aims to outline the various roles of autophagy in BPH and elucidate potential therapeutic strategies targeting autophagy for managing BPH.

References

Saito M, Tsounapi P, Oikawa R, Shimizu S, Honda M, Sejima T . Prostatic ischemia induces ventral prostatic hyperplasia in the SHR; possible mechanism of development of BPH. Sci Rep. 2014; 4:3822. PMC: 3897960. DOI: 10.1038/srep03822. View

Rub C, Wilkening A, Voos W . Mitochondrial quality control by the Pink1/Parkin system. Cell Tissue Res. 2016; 367(1):111-123. DOI: 10.1007/s00441-016-2485-8. View

Bento C, Renna M, Ghislat G, Puri C, Ashkenazi A, Vicinanza M . Mammalian Autophagy: How Does It Work?. Annu Rev Biochem. 2016; 85:685-713. DOI: 10.1146/annurev-biochem-060815-014556. View

Denton D, Kumar S . Autophagy-dependent cell death. Cell Death Differ. 2018; 26(4):605-616. PMC: 6460387. DOI: 10.1038/s41418-018-0252-y. View

Hong G, Kim K, Kim Y, Lee H, Kim H, Jung J . Decreased mitophagy aggravates benign prostatic hyperplasia in aged mice through DRP1 and estrogen receptor α. Life Sci. 2022; 309:120980. DOI: 10.1016/j.lfs.2022.120980. View

Huang G, He X, Xue Z, Long Y, Liu J, Cai J . Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by inducing autophagic apoptosis through endoplasmic reticulum stress. BMC Complement Med Ther. 2022; 22(1):125. PMC: 9074266. DOI: 10.1186/s12906-022-03610-4. View

Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J . Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells. Oncotarget. 2016; 7(5):5366-82. PMC: 4868692. DOI: 10.18632/oncotarget.6783. View

Hornung V, Bauernfeind F, Halle A, Samstad E, Kono H, Rock K . Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008; 9(8):847-56. PMC: 2834784. DOI: 10.1038/ni.1631. View

Morales A . Androgen replacement therapy and prostate safety. Eur Urol. 2002; 41(2):113-20. DOI: 10.1016/s0302-2838(01)00039-2. View

10.

St Sauver J, Jacobson D, McGree M, Girman C, Lieber M, Jacobsen S . Longitudinal association between prostatitis and development of benign prostatic hyperplasia. Urology. 2008; 71(3):475-9. PMC: 2597174. DOI: 10.1016/j.urology.2007.11.155. View

11.

Ryter S, Mizumura K, Choi A . The impact of autophagy on cell death modalities. Int J Cell Biol. 2014; 2014:502676. PMC: 3932252. DOI: 10.1155/2014/502676. View

12.

Nicholson T, Ricke W . Androgens and estrogens in benign prostatic hyperplasia: past, present and future. Differentiation. 2011; 82(4-5):184-99. PMC: 3179830. DOI: 10.1016/j.diff.2011.04.006. View

13.

Li Y, Zhou Y, Liu D, Wang Z, Qiu J, Zhang J . Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate. J Transl Med. 2023; 21(1):575. PMC: 10463608. DOI: 10.1186/s12967-023-04432-9. View

14.

Chang W, Tsai Y, Wang J, Chen H, Yang W, Lee C . Sex hormones and oxidative stress mediated phthalate-induced effects in prostatic enlargement. Environ Int. 2019; 126:184-192. DOI: 10.1016/j.envint.2019.02.006. View

15.

Hasan K, Haque M . Autophagy and Its Lineage-Specific Roles in the Hematopoietic System. Oxid Med Cell Longev. 2023; 2023:8257217. PMC: 10171987. DOI: 10.1155/2023/8257217. View

16.

Chughtai B, Lee R, Te A, Kaplan S . Role of inflammation in benign prostatic hyperplasia. Rev Urol. 2011; 13(3):147-50. PMC: 3221555. View

17.

Ye Y, Tyndall E, Bui V, Bewley M, Wang G, Hong X . Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy. Nat Commun. 2023; 14(1):5503. PMC: 10485044. DOI: 10.1038/s41467-023-41243-4. View

18.

Kim K, Hong G, Kim Y, Lee H, Jung J . Silencing of LLGL2 Suppresses the Estradiol-Induced BPH-1 Cell Proliferation through the Regulation of Autophagy. Biomedicines. 2022; 10(8). PMC: 9406103. DOI: 10.3390/biomedicines10081981. View

19.

Han S, Li X, Wang K, Zhu D, Meng B, Liu J . PURPL represses autophagic cell death to promote cutaneous melanoma by modulating ULK1 phosphorylation. Cell Death Dis. 2021; 12(11):1070. PMC: 8581000. DOI: 10.1038/s41419-021-04362-8. View

20.

Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X . Ferroptosis is an autophagic cell death process. Cell Res. 2016; 26(9):1021-32. PMC: 5034113. DOI: 10.1038/cr.2016.95. View