In-Fjord Substitution in Expanded Helicenes: Effects of the Insert on the Inversion Barrier and Helical Pitch

Overview

Journal Chemistry

Specialty Chemistry

Date 2021 Jul 21

PMID 34288171

Citations 5

Authors

Samuel Suarez-Pantiga

Pablo Redero

Xaiza Aniban

Martin Simon

Christopher Golz

Ricardo A Mata

Manuel Alcarazo

Affiliations

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Abstract

A series of expanded helicenes of different sizes and shapes incorporating phenyl- and biphenyl-substituents at the deepest part of their fjord have been synthesized via sequential Au-catalyzed hydroarylation of appropriately designed diynes, and their racemization barriers have been calculated employing electronic structure methods. These show that the overall profile of the inversions (energies, number of transition states and intermediates, and their relative position) is intensively affected by the interplay of steric and attractive London dispersion interactions. Hence, in-fjord substitution constitutes an additional tool to handle the mechanical properties in helicenes of uncommonly large diameter. The photochemical characterization of the newly prepared helical structures is also reported.

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