Circulating MicroRNAs in Gastrointestinal Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Jul 20

PMID 34283058

Citations 8

Authors

Masahisa Ohtsuka

Kazuya Iwamoto

Atsushi Naito

Mitsunobu Imasato

Satoshi Hyuga

Yujiro Nakahara

Manabu Mikamori

Kenta Furukawa

Jeongho Moon

Tadafumi Asaoka

Kentaro Kishi

Awad Shamma

Hiroki Akamatsu

Tsunekazu Mizushima

Hirofumi Yamamoto

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal cancer (GIC) is a common disease and is considered to be the leading cause of cancer-related death worldwide; thus, new diagnostic and therapeutic strategies for GIC are urgently required. Noncoding RNAs (ncRNAs) are functional RNAs that are transcribed from the genome but do not encode proteins. MicroRNAs (miRNAs) are short ncRNAs that are reported to function as both oncogenes and tumor suppressors. Moreover, several miRNA-based drugs are currently proceeding to clinical trials for various diseases, including cancer. In recent years, the stability of circulating miRNAs in blood has been demonstrated. This is of interest because these miRNAs could be potential noninvasive biomarkers of cancer. In this review, we focus on circulating miRNAs associated with GIC and discuss their potential as novel biomarkers.

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References

Imamoto R, Okano J, Sawada S, Fujise Y, Abe R, Murawaki Y . Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats. Exp Ther Med. 2013; 7(1):31-38. PMC: 3861306. DOI: 10.3892/etm.2013.1391. View

Habieb A, Matboli M, El-Tayeb H, El-Asmar F . Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma. Mol Biol Rep. 2019; 46(4):4581-4590. DOI: 10.1007/s11033-019-04810-x. View

Gokita K, Inoue J, Ishihara H, Kojima K, Inazawa J . Therapeutic Potential of LNP-Mediated Delivery of miR-634 for Cancer Therapy. Mol Ther Nucleic Acids. 2019; 19:330-338. PMC: 6938807. DOI: 10.1016/j.omtn.2019.10.045. View

Montecalvo A, Larregina A, Shufesky W, Stolz D, Sullivan M, Karlsson J . Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2011; 119(3):756-66. PMC: 3265200. DOI: 10.1182/blood-2011-02-338004. View

Haraszti R, Didiot M, Sapp E, Leszyk J, Shaffer S, Rockwell H . High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. J Extracell Vesicles. 2016; 5:32570. PMC: 5116062. DOI: 10.3402/jev.v5.32570. View

Sugimachi K, Matsumura T, Hirata H, Uchi R, Ueda M, Ueo H . Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer. 2015; 112(3):532-8. PMC: 4453648. DOI: 10.1038/bjc.2014.621. View

Zhou X, Wen W, Zhu J, Huang Z, Zhang L, Zhang H . A six-microRNA signature in plasma was identified as a potential biomarker in diagnosis of esophageal squamous cell carcinoma. Oncotarget. 2017; 8(21):34468-34480. PMC: 5470983. DOI: 10.18632/oncotarget.16519. View

Takahashi R, Prieto-Vila M, Kohama I, Ochiya T . Development of miRNA-based therapeutic approaches for cancer patients. Cancer Sci. 2019; 110(4):1140-1147. PMC: 6447849. DOI: 10.1111/cas.13965. View

Catalano V, Labianca R, Beretta G, Gatta G, De Braud F, Van Cutsem E . Gastric cancer. Crit Rev Oncol Hematol. 2009; 71(2):127-64. DOI: 10.1016/j.critrevonc.2009.01.004. View

10.

Wu Q, Lu Z, Li H, Lu J, Guo L, Ge Q . Next-generation sequencing of microRNAs for breast cancer detection. J Biomed Biotechnol. 2011; 2011:597145. PMC: 3118289. DOI: 10.1155/2011/597145. View

11.

Thomou T, Mori M, Dreyfuss J, Konishi M, Sakaguchi M, Wolfrum C . Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017; 542(7642):450-455. PMC: 5330251. DOI: 10.1038/nature21365. View

12.

Gallo A, Tandon M, Alevizos I, Illei G . The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One. 2012; 7(3):e30679. PMC: 3302865. DOI: 10.1371/journal.pone.0030679. View

13.

Margolis L, Sadovsky Y . The biology of extracellular vesicles: The known unknowns. PLoS Biol. 2019; 17(7):e3000363. PMC: 6667152. DOI: 10.1371/journal.pbio.3000363. View

14.

Dhayat S, Husing A, Senninger N, Schmidt H, Haier J, Wolters H . Circulating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma. PLoS One. 2015; 10(10):e0140066. PMC: 4598187. DOI: 10.1371/journal.pone.0140066. View

15.

Lin H, Zhang L, Zhang C, Liu P . Exosomal MiR-500a-3p promotes cisplatin resistance and stemness via negatively regulating FBXW7 in gastric cancer. J Cell Mol Med. 2020; 24(16):8930-8941. PMC: 7417713. DOI: 10.1111/jcmm.15524. View

16.

Schwarzenbach H, Nishida N, Calin G, Pantel K . Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol. 2014; 11(3):145-56. DOI: 10.1038/nrclinonc.2014.5. View

17.

Chen Y, Zhang J, Gong W, Dai W, Xu X, Xu S . miR-588 is a prognostic marker in gastric cancer. Aging (Albany NY). 2020; 13(2):2101-2117. PMC: 7880400. DOI: 10.18632/aging.202212. View

18.

Wikberg M, Myte R, Palmqvist R, van Guelpen B, Ljuslinder I . Plasma miRNA can detect colorectal cancer, but how early?. Cancer Med. 2018; 7(5):1697-1705. PMC: 5943420. DOI: 10.1002/cam4.1398. View

19.

Fu F, Jiang W, Zhou L, Chen Z . Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer. Transl Oncol. 2018; 11(2):221-232. PMC: 5789766. DOI: 10.1016/j.tranon.2017.12.012. View

20.

Liu X, Pan B, Sun L, Chen X, Zeng K, Hu X . Circulating Exosomal miR-27a and miR-130a Act as Novel Diagnostic and Prognostic Biomarkers of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2018; 27(7):746-754. DOI: 10.1158/1055-9965.EPI-18-0067. View