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Impaired Semen Parameters in Patients with Confirmed SARS-CoV-2 Infection: A Prospective Cohort Study

Overview
Journal Andrologia
Date 2021 Jul 16
PMID 34268784
Citations 31
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Abstract

In this prospective study, we investigated the impact of SARS-CoV-2 infection on semen parameters in a cohort of men who had recently recovered from COVID-19. A total of 24 men who had recently recovered from mild COVID-19 were included in the study. Their semen parameters were normal before COVID-19 according to the World Health Organization 2010 reference values. Semen samples were collected from these participants in the recovery phases of COVID-19. To determine the effect of SARS-CoV-2 infection on semen parameters, the patients' pre-COVID-19 and post-COVID-19 semen analyses were compared. The mean age of the participants was 34.7 ± 6.4 years. The median interval between the positive nasopharyngeal swab test and obtaining semen samples was 111.5 (158) days. There was no significant difference in semen parameters before and after COVID-19 in terms of semen volume (p = .56), sperm concentration (p = .06), and progressive motility (p = .14). Total motility (p = .01) and total motile sperm count (p = .02) decreased significantly after SARS-CoV-2 infection compared to the pre-infection values. This study demonstrated that sperm motility and total motile sperm count were the semen parameters which showed a significant reduction in cases with a history of mild COVID-19.

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References
1.
Wang Z, Xu X . scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020; 9(4). PMC: 7226809. DOI: 10.3390/cells9040920. View

2.
Aitken R . COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission?. Andrology. 2020; 9(1):48-52. PMC: 7404878. DOI: 10.1111/andr.12859. View

3.
Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O . Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril. 2020; 114(2):233-238. PMC: 7256599. DOI: 10.1016/j.fertnstert.2020.05.028. View

4.
Gralinski L, Menachery V . Return of the Coronavirus: 2019-nCoV. Viruses. 2020; 12(2). PMC: 7077245. DOI: 10.3390/v12020135. View

5.
Jung A, Schuppe H . Influence of genital heat stress on semen quality in humans. Andrologia. 2007; 39(6):203-15. DOI: 10.1111/j.1439-0272.2007.00794.x. View