Role of SARS-CoV-2-induced Cytokine Storm in Multi-organ Failure: Molecular Pathways and Potential Therapeutic Options

Overview

Journal Int Immunopharmacol

Specialties Allergy & Immunology
Pharmacology

Date 2022 Nov 15

PMID 36379152

Authors

Yasaman Nazerian

Mobina Ghasemi

Younes Yassaghi

Amirhossein Nazerian

Seyed Mahmoud Hashemi

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called "cytokine storm" is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19.

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