The Expression of Surface IgD on B Cells Responsive to Thymus-independent and Thymus-dependent Antigens and Its Requirement for B-cell Triggering

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1983 Feb 1

PMID 6337091

Citations 6

Authors

S Marshall-Clarke

K D Keeler

M E Parkhouse

Affiliations

Soon will be listed here.

Abstract

Cells separated by the fluorescence activated cell sorter on the basis of their surface IgD (sIgD) phenotype have been examined for responsiveness to thymus-dependent and thymus-independent antigens. The ability of monoclonal anti-IgD alloantibodies to inhibit responses in vitro to the various classes of antigen has also been investigated. Evidence is presented indicating that both sIgD positive and sIgD negative cells can respond to all types of antigen tested. However, although the presence of sIgD was necessary for the response of sIgD positive cells to thymus-dependent antigens, the presence of this isotype was not obligatory for the response of the sIgD positive population to thymus independent antigens. The possible role of sIgD as the obligatory purveyor of a B-cell activation signal is discussed in the light of these findings.

Citing Articles

Function of IgD in B cell triggering and tolerance: an overview of recent advances.

Phipps R, Scott D Surv Immunol Res. 1984; 3(2-3):195-7.

PMID: 6609402 DOI: 10.1007/BF02918793.

Pretreatment of mice with anti-IgD serum does not result in suppression of immune responsiveness induced by TNP-AECM-Ficoll or lipopolysaccharide.

Dresser D, Parkhouse R, Popham A Immunology. 1983; 48(3):497-501.

PMID: 6337946 PMC: 1454034.

Functional differences associated with quantitative distribution of membrane immunoglobulin, Fc receptors and Ia on mouse B cells.

Andrew E, Mackenzie N, Parkhouse R Immunology. 1985; 54(2):233-40.

PMID: 3881338 PMC: 1453500.

Independent regulation of IgM, IgD, and Ia antigen expression in cultured immature B lymphocytes.

Dasch J, Jones P J Exp Med. 1986; 163(4):938-51.

PMID: 3485174 PMC: 2188065. DOI: 10.1084/jem.163.4.938.

Assessment of antigen-specific receptor function of surface immunoglobulin M and D with identical hapten specificity.

Tisch R, Watanabe M, Letarte M, Hozumi N Proc Natl Acad Sci U S A. 1987; 84(11):3831-5.

PMID: 3108881 PMC: 304970. DOI: 10.1073/pnas.84.11.3831.

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