Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Jul 2

PMID 34205522

Citations 5

Authors

Mirinae Kim

Jae-Yon Won

Seung-Yong Choi

Minhee Kim

Ho Ra

Donghyun Jee

Jin-Woo Kwon

Kui-Dong Kang

Young-Jung Roh

Young-Gun Park

Seungbum Kang

Jeong-Ah Shin

Hyeon-Woo Yim

Young-Hoon Park

Affiliations

Soon will be listed here.

Abstract

We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multicenter, prospective, interventional randomized controlled trial was conducted from March 2017 to April 2020. Participants were randomly allocated to a PPV group or a PPV+APC group. All participants underwent standard 25-gauge PPV, and eyes in the PPV+APC group underwent PPV with intravitreal APC injection before air-gas exchange. A total of 117 patients were enrolled (PPV group: = 59, PPV+APC group: = 58). Hole closure was achieved in 47 participants (79.7%) in the PPV group and 52 participants (89.7%) in the PPV+APC group. There were no between-group differences in the anatomical closure rate or functional outcomes including best-corrected visual acuity, metamorphopsia, pattern-reversal visual evoked potential, or Visual Function Questionnaire-25 score. The use of APC injection does not improve the anatomical and functional outcomes of surgery for large MHs, recurrent MHs, or MHs with high myopia. The adjunctive use of APC can be considered in selected cases because it is not inferior to conventional MH surgery, is relatively simple to perform, and is not affected by the surgeon's skill.

Citing Articles

Long-term outcomes and prognosis in vitrectomy with autologous platelet concentrate injection for large, high myopic, or recurrent macular holes.

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Autologous platelet concentrate for the treatment of macular hole: a systematic review and meta-analysis.

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