The Effect of Platelet Releasate on Wound Healing in Animal Models

Overview

Journal J Am Acad Dermatol

Specialty Dermatology

Date 1990 May 1

PMID 2347964

Citations 7

Authors

G A Ksander

S J Sawamura

Y Ogawa

J Sundsmo

J M McPherson

Affiliations

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Abstract

The alpha granules of platelets contain growth factors that are important in wound healing. We found that a major effect of thrombin-induced human platelet releasates in animal models of wound healing is to enhance the development of granulation tissue and new connective tissue matrix. These studies provide further evidence that platelet-derived protein factors may be useful in treating full-thickness dermal wounds by increasing the rate of granulation tissue formation.

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