Cell-Secreted Vesicles: Novel Opportunities in Cancer Diagnosis, Monitoring and Treatment

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2021 Jul 2

PMID 34205256

Citations 5

Authors

Cristina Catoni

Veronica Di Paolo

Elisabetta Rossi

Luigi Quintieri

Rita Zamarchi

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are important mediators of intercellular communication playing a pivotal role in the regulation of physiological and pathological processes, including cancer. In particular, there is significant evidence suggesting that tumor-derived EVs exert an immunosuppressive activity during cancer progression, as well as stimulate tumor cell migration, angiogenesis, invasion and metastasis. The use of EVs as a liquid biopsy is currently a fast-growing area of research in medicine, with the potential to provide a step-change in the diagnosis and treatment of cancer, allowing the prediction of both therapy response and prognosis. EVs could be useful not only as biomarkers but also as drug delivery systems, and may represent a target for anticancer therapy. In this review, we attempted to summarize the current knowledge about the techniques used for the isolation of EVs and their roles in cancer biology, as liquid biopsy biomarkers and as therapeutic tools and targets.

Citing Articles

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References

Matsumura T, Sugimachi K, Iinuma H, Takahashi Y, Kurashige J, Sawada G . Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. Br J Cancer. 2015; 113(2):275-81. PMC: 4506387. DOI: 10.1038/bjc.2015.201. View

Brett S, Lucien F, Guo C, Williams K, Kim Y, Durfee P . Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples. Prostate. 2017; 77(13):1335-1343. DOI: 10.1002/pros.23393. View

Rana S, Yue S, Stadel D, Zoller M . Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection. Int J Biochem Cell Biol. 2012; 44(9):1574-84. DOI: 10.1016/j.biocel.2012.06.018. View

Luga V, Zhang L, Viloria-Petit A, Ogunjimi A, Inanlou M, Chiu E . Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 2012; 151(7):1542-56. DOI: 10.1016/j.cell.2012.11.024. View

Yang Y, Li C, Chan L, Wei Y, Hsu J, Xia W . Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res. 2018; 28(8):862-864. PMC: 6082826. DOI: 10.1038/s41422-018-0060-4. View

van der Pol E, Boing A, Gool E, Nieuwland R . Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J Thromb Haemost. 2015; 14(1):48-56. DOI: 10.1111/jth.13190. View

Miyoshi H, Umeshita K, Sakon M, Imajoh-Ohmi S, Fujitani K, Gotoh M . Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Gastroenterology. 1996; 110(6):1897-904. DOI: 10.1053/gast.1996.v110.pm8964416. View

Vagner T, Spinelli C, Minciacchi V, Balaj L, Zandian M, Conley A . Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J Extracell Vesicles. 2018; 7(1):1505403. PMC: 6084494. DOI: 10.1080/20013078.2018.1505403. View

Xie X, Nie H, Zhou Y, Lian S, Mei H, Lu Y . Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles. Nat Commun. 2019; 10(1):5476. PMC: 6889386. DOI: 10.1038/s41467-019-13316-w. View

10.

Del Re M, van Schaik R, Fogli S, Mathijssen R, Cucchiara F, Capuano A . Blood-based PD-L1 analysis in tumor-derived extracellular vesicles: Applications for optimal use of anti-PD-1/PD-L1 axis inhibitors. Biochim Biophys Acta Rev Cancer. 2020; 1875(1):188463. DOI: 10.1016/j.bbcan.2020.188463. View

11.

Pang W, Su J, Wang Y, Feng H, Dai X, Yuan Y . Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts. Cancer Sci. 2015; 106(10):1362-9. PMC: 4638007. DOI: 10.1111/cas.12747. View

12.

Huyan T, Li H, Peng H, Chen J, Yang R, Zhang W . Extracellular Vesicles - Advanced Nanocarriers in Cancer Therapy: Progress and Achievements. Int J Nanomedicine. 2020; 15:6485-6502. PMC: 7457829. DOI: 10.2147/IJN.S238099. View

13.

Kucharzewska P, Belting M . Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress. J Extracell Vesicles. 2013; 2. PMC: 3760648. DOI: 10.3402/jev.v2i0.20304. View

14.

Jahn R, Scheller R . SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol. 2006; 7(9):631-43. DOI: 10.1038/nrm2002. View

15.

Lima L, Oliveira A, Campos L, Bonamino M, Chammas R, Werneck C . Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles. Thromb Haemost. 2011; 106(4):712-23. DOI: 10.1160/TH11-03-0143. View

16.

Richards K, Zeleniak A, Fishel M, Wu J, Littlepage L, Hill R . Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells. Oncogene. 2016; 36(13):1770-1778. PMC: 5366272. DOI: 10.1038/onc.2016.353. View

17.

Sugahara K, Teesalu T, Karmali P, Kotamraju V, Agemy L, Greenwald D . Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science. 2010; 328(5981):1031-5. PMC: 2881692. DOI: 10.1126/science.1183057. View

18.

Giusti I, Delle Monache S, Di Francesco M, Sanita P, DAscenzo S, Gravina G . From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis. Tumour Biol. 2016; 37(9):12743-12753. DOI: 10.1007/s13277-016-5165-0. View

19.

Carvalho C, Santos R, Cardoso S, Correia S, Oliveira P, Santos M . Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem. 2009; 16(25):3267-85. DOI: 10.2174/092986709788803312. View

20.

Meldolesi J . Exosomes and Ectosomes in Intercellular Communication. Curr Biol. 2018; 28(8):R435-R444. DOI: 10.1016/j.cub.2018.01.059. View