Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma

Overview

Journal Curr Oncol

Publisher MDPI

Specialty Oncology

Date 2022 Aug 25

PMID 36005165

Authors

Qian Zhang

Hanlin Li

Yang Liu

Jian Li

Chunling Wu

Hua Tang

Affiliations

Soon will be listed here.

Abstract

Exosomes, extracellular vesicles with a diameter of 40 to 160 nm, are among the smallest extracellular vesicles released by cells. They deliver different cargoes, including proteins, DNAs, and RNAs, and facilitate communication between cells to coordinate a variety of physiological and pathological functions. Hepatocellular carcinoma (HCC) is the sixth common malignant tumor and the fourth leading cause of cancer-related death worldwide. Its molecular mechanism remains largely unknown, and there is a lack of reliable and noninvasive biomarkers for early diagnosis and prognosis prediction. Mounting evidence has shown that exosomes carry a variety of ncRNAs, such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which play critical roles in the occurrence and progression of HCC. In this review, we summarize the recent findings of exosomal miRNAs, lncRNAs, and circRNAs in HCC from their impact on the development of HCC to their potential applications in the diagnosis and treatment of HCC.

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References

Savina A, Furlan M, Vidal M, Colombo M . Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J Biol Chem. 2003; 278(22):20083-90. DOI: 10.1074/jbc.M301642200. View

Sanger H, KLOTZ G, Riesner D, Gross H, KLEINSCHMIDT A . Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976; 73(11):3852-6. PMC: 431239. DOI: 10.1073/pnas.73.11.3852. View

Lin Q, Zhou C, Bai M, Zhu D, Chen J, Wang H . Exosome-mediated miRNA delivery promotes liver cancer EMT and metastasis. Am J Transl Res. 2020; 12(3):1080-1095. PMC: 7137059. View

Cao L, Yang X, Chen Y, Zhang D, Jiang X, Xue P . Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth. Mol Cancer. 2019; 18(1):148. PMC: 6815431. DOI: 10.1186/s12943-019-1075-2. View

Hinshaw D, Shevde L . The Tumor Microenvironment Innately Modulates Cancer Progression. Cancer Res. 2019; 79(18):4557-4566. PMC: 6744958. DOI: 10.1158/0008-5472.CAN-18-3962. View

Nakano T, Chen I, Wang C, Chen P, Tseng H, Huang K . Circulating exosomal miR-92b: Its role for cancer immunoediting and clinical value for prediction of posttransplant hepatocellular carcinoma recurrence. Am J Transplant. 2019; 19(12):3250-3262. DOI: 10.1111/ajt.15490. View

Takahashi K, Yan I, Wood J, Haga H, Patel T . Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res. 2014; 12(10):1377-87. PMC: 4201956. DOI: 10.1158/1541-7786.MCR-13-0636. View

Qin L, Zhan Z, Wei C, Li X, Zhang T, Li J . Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer. Mol Med Rep. 2021; 23(6). PMC: 8025462. DOI: 10.3892/mmr.2021.12060. View

Chen L, Heikkinen L, Wang C, Yang Y, Sun H, Wong G . Trends in the development of miRNA bioinformatics tools. Brief Bioinform. 2018; 20(5):1836-1852. PMC: 7414524. DOI: 10.1093/bib/bby054. View

10.

Frundt T, Krause L, Hussey E, Steinbach B, Kohler D, von Felden J . Diagnostic and Prognostic Value of miR-16, miR-146a, miR-192 and miR-221 in Exosomes of Hepatocellular Carcinoma and Liver Cirrhosis Patients. Cancers (Basel). 2021; 13(10). PMC: 8161187. DOI: 10.3390/cancers13102484. View

11.

Jandura A, Krause H . The New RNA World: Growing Evidence for Long Noncoding RNA Functionality. Trends Genet. 2017; 33(10):665-676. DOI: 10.1016/j.tig.2017.08.002. View

12.

Hu K, Li N, Li J, Chen Z, Wang J, Sheng L . Exosome circCMTM3 promotes angiogenesis and tumorigenesis of hepatocellular carcinoma through miR-3619-5p/SOX9. Hepatol Res. 2021; 51(11):1139-1152. DOI: 10.1111/hepr.13692. View

13.

Li Y, Zang H, Zhang X, Huang G . Exosomal Circ-ZNF652 Promotes Cell Proliferation, Migration, Invasion and Glycolysis in Hepatocellular Carcinoma via miR-29a-3p/GUCD1 Axis. Cancer Manag Res. 2020; 12:7739-7751. PMC: 7473989. DOI: 10.2147/CMAR.S259424. View

14.

Pathan M, Fonseka P, Chitti S, Kang T, Sanwlani R, Van Deun J . Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles. Nucleic Acids Res. 2018; 47(D1):D516-D519. PMC: 6323905. DOI: 10.1093/nar/gky1029. View

15.

Bebelman M, Smit M, Pegtel D, Baglio S . Biogenesis and function of extracellular vesicles in cancer. Pharmacol Ther. 2018; 188:1-11. DOI: 10.1016/j.pharmthera.2018.02.013. View

16.

Henne W, Buchkovich N, Emr S . The ESCRT pathway. Dev Cell. 2011; 21(1):77-91. DOI: 10.1016/j.devcel.2011.05.015. View

17.

Vietri M, Radulovic M, Stenmark H . The many functions of ESCRTs. Nat Rev Mol Cell Biol. 2019; 21(1):25-42. DOI: 10.1038/s41580-019-0177-4. View

18.

Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A . Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2009; 12(1):19-30. DOI: 10.1038/ncb2000. View

19.

Thery C, Zitvogel L, Amigorena S . Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2(8):569-79. DOI: 10.1038/nri855. View

20.

Huang X, Sun L, Wen S, Deng D, Wan F, He X . RNA sequencing of plasma exosomes revealed novel functional long noncoding RNAs in hepatocellular carcinoma. Cancer Sci. 2020; 111(9):3338-3349. PMC: 7469810. DOI: 10.1111/cas.14516. View