Long-term Spontaneous Regression of Stage IV Diffuse Large B-cell Lymphoma

Overview

Journal J Clin Exp Hematop

Specialties Hematology
Pathology

Date 2021 Jul 1

PMID 34193754

Citations 1

Authors

Yoshiki Furukawa

Jun Ando

Miki Ando

Shintaro Kinoshita

Yoko Edahiro

Takuya Furuta

Koichi Ohshima

Norio Komatsu

Affiliations

Soon will be listed here.

Abstract

Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for >42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.

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