Spontaneous Remission in Diffuse Large Cell Lymphoma: a Case Report

Overview

Journal J Med Case Rep

Publisher Biomed Central

Specialty General Medicine

Date 2019 Feb 3

PMID 30709425

Citations 10

Authors

J Snijder

N Mihyawi

A Frolov

A Ewton

G Rivero

Affiliations

Soon will be listed here.

Abstract

Background: Spontaneous remission in solid malignancies has been documented. However, spontaneous remission in aggressive diffuse large b cell lymphoma is exceedingly rare. Previous reports of lymphoma remission suggest that not yet fully characterized tumor-intrinsic and microenvironment mechanisms cooperate with spontaneous regression.

Case Description: Here, we report the case of an 88-year-old white woman with diffuse large b cell lymphoma (follicular lymphoma transformed) who achieved morphologic spontaneous remission 3 months after her diagnostic core biopsy. We examined 16 similar cases of diffuse large b cell lymphoma suggesting that spontaneous remission is preferentially observed in elderly patients soon after their biopsy microtrauma, especially if malignancies are Epstein-Barr virus driven and activated B-cell type.

Conclusion: Our case and reported analysis highlight that anti-tumor adaptive T cell responses are potentially augmented in a subset of patients leading to lymphoma regression. In these patients, it is possible that "primed" innate anti-tumor T cell immunity is enhanced in immunogenic lymphoma subtypes after tissue biopsy. Our case and analysis not only reinforce the role of innate T cell anticancer immunity, but also originates potential proof of concept for investigation of unexplored pathways that could favorably impact T cell therapy.

Citing Articles

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Spontaneous regression of primary cutaneous diffuse large B-cell lymphoma, leg type: A case series and review of the literature.

Winkler M, Albrecht J, Sauer C, Kordass T, Guenova E, Livingstone E J Dermatol. 2024; 51(9):1233-1239.

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Spontaneous Regression of Diffuse Large B-cell Lymphoma in a Patient with Ataxia-Telangiectasia.

Sherkat R, Moghaddam N, Reisi N, Rezaei M Adv Biomed Res. 2022; 11:31.

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Secondary vitreoretinal lymphoma with spontaneous regression.

Kongwattananon W, Kumar A, Simard J, Wiley H, Sen H, Kodati S Am J Ophthalmol Case Rep. 2022; 25:101357.

PMID: 35146209 PMC: 8818703. DOI: 10.1016/j.ajoc.2022.101357.

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