Small-cell Lung Cancer Exhibiting Spontaneous Regression

Overview

Journal Intern Med

Specialty General Medicine

Date 2013 Oct 4

PMID 24088761

Citations 5

Authors

Shin-Ichiro Iwakami

Mitsuhiro Fujii

Toshiji Ishiwata

Naoko Iwakami

Munechika Hara

Hiroaki Ihara

Ryo Wada

Takeo Tsutsumi

Kuniaki Seyama

Kazuhisa Takahashi

Affiliations

Soon will be listed here.

Abstract

A 56-year-old woman was admitted to our hospital because a chest X-ray and thoracic computed tomography (CT) scan revealed a heterogeneous tumor in the middle mediastinum during a visit to a nearby clinic for a consultation regarding a persistent cough and body weight loss. However, the tumor spontaneously decreased on thoracic CT performed on admission. Subsequently, a biopsy of the tumor using video-assisted thoracoscopy was performed. The pathological findings disclosed the tumor to be small-cell lung cancer with infiltration of CD8-positive T-cells exhibiting spontaneous regression. Cell-mediated immunity, including CD8-positive T-cells, may have relevance to the spontaneous regression of malignant tumors.

Citing Articles

Pathologically confirmed spontaneous regression of small cell lung cancer after computed tomography-guided percutaneous transthoracic needle biopsy followed by surgery.

Goto M, Fukumoto K, Ichikawa Y, Tsubouchi H, Uchiyama M, Mori S Surg Case Rep. 2023; 9(1):187.

PMID: 37878146 PMC: 10600075. DOI: 10.1186/s40792-023-01759-9.

Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report.

Otani M, Nishimori M, Iwasa H, Iwamura M, Izumi T, Nakaji K Radiol Case Rep. 2023; 18(11):4036-4041.

PMID: 37680668 PMC: 10480669. DOI: 10.1016/j.radcr.2023.08.059.

Programmed Death-Ligand 1-Positive Squamous Cell Carcinoma Spontaneously Regressed after Percutaneous Needle Biopsy.

Sasahara M, Takahashi H, Ohchi T, Nomura N, Kodama K, Ikeda K Medicina (Kaunas). 2023; 59(3).

PMID: 36984632 PMC: 10055785. DOI: 10.3390/medicina59030631.

Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma.

Furukawa Y, Ando J, Ando M, Kinoshita S, Edahiro Y, Furuta T J Clin Exp Hematop. 2021; 61(3):168-172.

PMID: 34193754 PMC: 8519247. DOI: 10.3960/jslrt.21002.

Spontaneous regression of non-small cell lung cancer after biopsy of a mediastinal lymph node metastasis: a case report.

Lopez-Pastorini A, Plones T, Brockmann M, Ludwig C, Beckers F, Stoelben E J Med Case Rep. 2015; 9:217.

PMID: 26377170 PMC: 4573999. DOI: 10.1186/s13256-015-0702-9.